| Item type |
文献 / Documents(1) |
| 公開日 |
2022-03-14 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.1016/j.yclnex.2020.03.001 |
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|
関連名称 |
10.1016/j.yclnex.2020.03.001 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
A non-obese, diet-induced animal model of nonalcoholic steatohepatitis in Wistar/ST rats compared to Sprague-Dawley rats |
| 著者 |
オオマガリ, カツヒサ
スズタ, マサコ
タニグチ, アサミ
クマモト, リサ
コヤマ, ユウコ
フクダ, アユミ
スルガ, カズヒト
(市村)清水, 真祐子
常山, 幸一
|
| 抄録 |
|
|
内容記述 |
Background: Non-alcoholic steatohepatitis (NASH), a subtype of non-alcoholic fatty liver disease (NAFLD), is a potentially progressive liver disease that can lead to cirrhosis. Obesity increases the risk of NAFLD/NASH, but this disease can also be observed in non-obese individuals.
Methods: We investigated the metabolic and histopathological changes in 13 obesity-resistant Slc:Wistar/ST rats fed a high-fat and high-cholesterol (HFC) diet for 9 weeks, and also retrospectively compared the results of 41 Sprague-Dawley (SD) rats that were previously fed with the same protocol to the results of the Slc:Wistar/ST rats.
Results: Of the 13 Slc:Wistar/ST rats fed an HFC diet containing 1.25% or 2.5% cholesterol, 11 (84.6%) developed histologically proven NASH without obesity, an increased visceral fat volume, insulin resistance, histopatological severe lobular inflammation and severe hepatic fibrosis. The HFC diets significantly increased the levels of mRNA encoding collagen type I alpha 1 (COL1A1), transforming growth factor-β1 (TGF-β1), tumor necrosis factor-α (TNF-α) and monocyte chemoattractant protein-1 (MCP-1). The SD rats also developed NASH without obesity, an increased visceral fat volume and insulin resistance, but the metabolic and histopathological effects, such as lower serum adiponectin levels, higher serum leptin levels, histopatological severe lobular inflammation and hepatic fibrosis, seemed to be more pronounced in the SD rats than in the Slc:Wistar/ST rats.
Conclusions: These two rat models may reflect the human etiology of NASH that is influenced by dietary factors, and the obesity-resistant Slc:Wistar/ST rat model may be particularly useful for elucidating the pathophysiological mechanism of the so-called “lean NASH”. |
| キーワード |
|
|
主題 |
Non-alcoholic fatty liver disease |
| キーワード |
|
|
主題 |
Obesity |
| キーワード |
|
|
主題 |
Wistar rat |
| キーワード |
|
|
主題 |
Sprague-Dawley rat |
| キーワード |
|
|
主題 |
High-fat diet |
| キーワード |
|
|
主題 |
Cholesterol |
| 書誌情報 |
en : Clinical Nutrition Experimental
巻 30,
p. 1-14,
発行日 2020-03-14
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| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
23529393 |
| 出版者 |
|
|
出版者 |
Elsevier |
| 出版者 |
|
|
出版者 |
European Society for Clinical Nutrition and Metabolism |
| 権利情報 |
|
|
権利情報 |
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| EID |
|
|
識別子 |
382758 |
| 言語 |
|
|
言語 |
eng |
clnex_30_1.pdf (1.13 MB)
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