| Item type |
文献 / Documents(1) |
| 公開日 |
2022-02-21 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.52586/5042 |
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|
言語 |
ja |
|
|
関連名称 |
10.52586/5042 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Phospho-Smad3 signaling is predictive biomarker for hepatocellular carcinoma risk assessment in primary biliary cholangitis patients |
|
言語 |
en |
| 著者 |
ナカムラ, ナオヒロ
ヨシダ, カツノリ
ツダ, リナコ
ムラタ, ミキ
ヤマグチ, タカシ
スワ, カネヒコ
(市村)清水, 真祐子
常山, 幸一
マツザキ, コウイチ
ナカノ, トシアキ
ヒロハラ, ジュンコ
セキ, トシヒト
オカザキ, カズイチ
Gershwin, M. Eric
ナガヌマ, マコト
|
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Introduction: Patients with primary biliary cholangitis (PBC) are at increased risk for development of hepatocellular carcinoma (HCC), particularly in the presence of comorbidities such as excessive alcohol consumption. Although liver fibrosis is an important risk factor for HCC development, earlier predictors of future HCC development in livers with little fibrosis are needed but not well defined. The transforming growth factor (TGF)-β/Smad signaling pathway participates importantly in hepatic carcinogenesis. Phosphorylated forms (phospho-isoforms) in Smad-related pathways can transmit opposing signals: cytostatic C-terminally-phosphorylated Smad3 (pSmad3C) and carcinogenic linker-phosphorylated Smad3 (pSmad3L) signals. Methods and results: To assess the balance between Smad signals as a biomarker of risk, we immunohistochemically compared Smad domain-specific Smad3 phosphorylation patterns among 52 PBC patients with various stages of fibrosis and 25 non-PBC patients with chronic hepatitis C virus infection. HCC developed in 7 of 11 PBC patients showing high pSmad3L immunoreactivity, but in only 2 of 41 PBC patients with low pSmad3L. In contrast, 9 of 20 PBC patients with minimal Smad3C phosphorylation developed HCC, while HCC did not occur during follow-up in 32 patients who retained hepatic tumor-suppressive pSmad3C. Further, PBC patients whose liver specimens showed high pSmad3L positivity were relatively likely to develop HCC even when little fibrosis was evident. Conclusion: In this study, Smad phospho-isoform status showed promise as a biomarker predicting likelihood of HCC occurrence in PBC. Eventually, therapies to shift favorably Smad phospho-isoforms might decrease likelihood of PBC-related HCC. |
|
言語 |
en |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
TGF-β |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
PBC |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Smad |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
HCC |
| 書誌情報 |
en : Frontiers in Bioscience-Landmark
巻 26,
号 12,
p. 1480-1492,
発行日 2021-12-30
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| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
27686701 |
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
27686698 |
| 出版者 |
|
|
出版者 |
IMR Press |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/). |
| EID |
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|
識別子 |
384229 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
fbl_26_12_1480.pdf (5.67 MB)
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