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アイテム
Emerging Roles of the Innate Immune System Regulated by DNA Sensors in the Development of Vascular and Metabolic Diseases
https://tokushima-u.repo.nii.ac.jp/records/2009874
https://tokushima-u.repo.nii.ac.jp/records/2009874445ea481-0c21-400f-93db-df0ae8b824b9
| 名前 / ファイル | ライセンス | アクション |
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jat_29_3_297.pdf (613 KB)
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| アイテムタイプ | 文献 / Documents(1) | |||||||||||||
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| 公開日 | 2022-06-15 | |||||||||||||
| アクセス権 | ||||||||||||||
| アクセス権 | open access | |||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | journal article | |||||||||||||
| 出版社版DOI | ||||||||||||||
| 関連識別子 | https://doi.org/10.5551/jat.RV17059 | |||||||||||||
| 関連名称 | 10.5551/jat.RV17059 | |||||||||||||
| 出版タイプ | ||||||||||||||
| 出版タイプ | VoR | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Emerging Roles of the Innate Immune System Regulated by DNA Sensors in the Development of Vascular and Metabolic Diseases | |||||||||||||
| タイトル別表記 | ||||||||||||||
| その他のタイトル | DNA Sensors in Vascular and Metabolic Diseases | |||||||||||||
| 著者 |
福田, 大受
× 福田, 大受× Pham, Phuong Tran
× 佐田, 政隆
WEKO
309
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| 抄録 | ||||||||||||||
| 内容記述 | Sterile chronic inflammation causes cardiometabolic disorders; however, the mechanisms are not fully understood. Previous studies have demonstrated the degradation of cells/tissues in the vasculature and metabolic organs in lifestyle-associated diseases, such as diabetes and hyperlipidemia, suggesting the release and/or accumulation of nucleic acids from damaged cells. DNA is indispensable for life; however, DNA fragments, especially those from pathogens, strongly induce inflammation by the activation of DNA sensors. Growing evidence suggests that DNA-sensing mechanisms, which are normally involved in self-defense against pathogens as the innate immune system, are associated with the progression of inflammatory diseases in response to endogenous DNA fragments. There are several types of DNA sensors in our bodies. Toll-like receptor 9 (TLR9)—one of the most studied DNA sensors—recognizes DNA fragments in endosome. In addition, stimulator of interferon genes (STING), which has recently been extensively investigated, recognizes cyclic GMP-AMP (cGAMP) generated from DNA fragments in the cytosol. Both TLR9 and STING are known to play pivotal roles in host defense as the innate immune system. However, recent studies have indicated that the activation of these DNA sensors in immune cells, such as macrophages, promotes inflammation leading to the development of vascular and metabolic diseases associated with lifestyle. In this review, we discuss recent advances in determining the roles of DNA sensors in these disease contexts. Revealing a novel mechanism of sterile chronic inflammation regulated by DNA sensors might facilitate clinical interventions for these health conditions. | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | DNA sensor | |||||||||||||
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| 主題 | TLR9 | |||||||||||||
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| 主題 | STING | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | Atherosclerosis | |||||||||||||
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| 主題 | Insulin resistance | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | Inflammation | |||||||||||||
| 書誌情報 |
en : Journal of Atherosclerosis and Thrombosis 巻 29, 号 3, p. 297-307, 発行日 2022-03-01 |
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| 収録物ID | ||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||
| 収録物識別子 | 18803873 | |||||||||||||
| 収録物ID | ||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||
| 収録物識別子 | 13403478 | |||||||||||||
| 出版者 | ||||||||||||||
| 出版者 | Japan Atherosclerosis Society | |||||||||||||
| 権利情報 | ||||||||||||||
| 権利情報 | This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License. | |||||||||||||
| EID | ||||||||||||||
| 識別子 | 384441 | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
