| Item type |
文献 / Documents(1) |
| 公開日 |
2022-05-17 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
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|
関連識別子 |
https://doi.org/10.2152/jmi.69.120 |
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関連名称 |
10.2152/jmi.69.120 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Taste receptor gene expression is associated with decreased eGFR in patients with diabetes |
| タイトル別表記 |
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その他のタイトル |
Taste receptor genes and renal function |
| 著者 |
ベップ, カナ
カワカミ, アユカ
ミシマ, ユウナ
堤, 理恵
黒田, 雅士
森, 博康
黒田, 暁生
松久, 宗英
阪上, 浩
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| 抄録 |
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内容記述 |
Dysgeusia is not only associated with zinc deficiency but also with certain drugs or diseases, including diabetes and renal failure. It often lowers the patient’s quality of life and hinders access to proper nutrition. The underlying mechanism is unclear and there is a lack of awareness among patients. Here, we focused on lingual taste receptor gene expression in diabetes and elucidated the relationship between taste receptor gene expression and renal function. Forty-seven patients with diabetes and 10 healthy subjects (control group) were enrolled. Lingual foliate papillae were scraped and the derived cDNA was quantified by real-time polymerase chain reaction. Dysgeusia was assessed using SALSAVE®. All statistical analyses were performed using JMP® software 13. The expression of T1R1 and T1R2 was significantly upregulated in type 2 diabetes patients as compared with that in healthy subjects (P < 0.01) but did not change in type 1 diabetes patients. T1R3 expression positively correlated and Scnn1 expression negatively correlated with estimated glomerular filtration rate, suggesting that altered taste receptor gene expression could reflect impaired renal function. Thus, alterations in T1R3 and Scnn1 expression in diabetes correlated with renal function. Taste receptor gene expression dysregulation could indicate dysgeusia associated with impaired renal function in patients with diabetes. |
| キーワード |
|
|
主題 |
Dysgeusia |
| キーワード |
|
|
主題 |
Diabetes |
| キーワード |
|
|
主題 |
eGFR |
| キーワード |
|
|
主題 |
Taste receptor gene |
| 書誌情報 |
en : The Journal of Medical Investigation
巻 69,
号 1-2,
p. 120-126,
発行日 2022-02
|
| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13496867 |
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13431420 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| 出版者 |
|
|
出版者 |
Tokushima University Faculty of Medicine |
| 備考 |
|
|
値 |
著者英表記誤記あり (誤)Munehisa Matsuhisa→(正)Munehide Matsuhisa |
| EID |
|
|
識別子 |
386004 |
| 言語 |
|
|
言語 |
eng |
jmi_69_1-2_120.pdf (453 KB)
