| Item type |
文献 / Documents(1) |
| 公開日 |
2022-05-18 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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|
関連識別子 |
https://doi.org/10.17996/anc.21-00124 |
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関連名称 |
10.17996/anc.21-00124 |
| 出版タイプ |
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出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
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|
タイトル |
The Utility of a Combination of 99mTc-MIBI Washout Imaging and Cardiac Magnetic Resonance Imaging in the Evaluation of Cardiomyopathy |
| タイトル別表記 |
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その他のタイトル |
Imaging of Cardiomyopathy |
| 著者 |
ヤマナカ, モリアキ
髙尾, 正一郎
大塚, 秀樹
音見, 暢一
苛原, 早保
クニカネ, ヤマト
タカシ, サトル
ヤマモト, アイリ
佐田, 政隆
原田, 雅史
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| 抄録 |
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内容記述 |
Background: In cardiomyopathy, 99mTc-MIBI washout can reflect mitochondrial dysfunction and late gadolinium enhancement (LGE) on cardiac magnetic imaging (MRI) is associated with tissue fibrosis. We sought to determine the relationship between 99mTc-MIBI uptake, 99mTc-MIBI washout, and LGE on MRI in patients with cardiomyopathy.
Methods: Twenty-one patients underwent rest myocardial perfusion scintigraphy at 45 minutes (early) and 4 hours (delayed) after intravenous 99mTc-MIBI administration and cardiac MRI. We assessed myocardial perfusion, 99mTc-MIBI washout, and LGE. We divided the left ventricle (LV) wall into 16 segments using a polar map. Then, we classified each segment into 5 groups according to 99mTc-MIBI uptake in early-rest images and washout. Additionally, we created a contingency table based on LGE presence/absence in the groups.
Results: We evaluated 336 segments in 21 patients. 99mTc-MIBI uptake was decreased in 168 segments in the early-rest 99mTc-MIBI images. 99mTc-MIBI washout was observed in 108 segments with either normal perfusion or reduced perfusion in the early-rest 99mTc-MIBI images. LGE was positive in 104 segments. A contingency table analysis with Fisher’s exact test showed that LGE was observed significantly more frequently in the segments with decreased 99mTc-MIBI uptake (p < 0.001). In segments without a decreased 99mTc-MIBI uptake, there was a significant correlation between increased 99mTc-MIBI washout and the presence of LGE (p = 0.033).
Conclusions: In cardiomyopathy, the mitochondrial dysfunction in the early stage is shown as 99mTc-MIBI washout, and fibrotic changes in the myocardium in advanced stages are shown as LGE on cardiac MRI. The severity of myocardial damage and the clinical stage of cardiomyopathy can be evaluated using multimodal imaging. |
| キーワード |
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主題 |
99mTc-MIBI |
| キーワード |
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主題 |
Cardiomyopathy |
| キーワード |
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|
主題 |
Late gadolinium enhancement (LGE) |
| キーワード |
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|
主題 |
Washout |
| 書誌情報 |
en : Annals of Nuclear Cardiology
巻 7,
号 1,
p. 8-16,
発行日 2021-08-31
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
24241741 |
| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
21893926 |
| 出版者 |
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出版者 |
The Japanese Society of Nuclear Cardiology |
| 言語 |
|
|
言語 |
eng |
anc_7_1_8.pdf (630 KB)
