| Item type |
文献 / Documents(1) |
| 公開日 |
2022-07-08 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3390/antibiotics11010010 |
|
|
言語 |
ja |
|
|
関連名称 |
10.3390/antibiotics11010010 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Autoinducer Analogs Can Provide Bactericidal Activity to Macrolides in Pseudomonas aeruginosa through Antibiotic Tolerance Reduction |
|
言語 |
en |
| 著者 |
アベ, ミズキ
村上, 圭史
廣島, 佑香
天羽, 崇
セベ, マユ
片岡, 佳子
藤猪, 英樹
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Macrolide antibiotics are used in treating Pseudomonas aeruginosa chronic biofilm infections despite their unsatisfactory antibacterial activity, because they display several special activities, such as modulation of the bacterial quorum sensing and immunomodulatory effects on the host. In this study, we investigated the effects of the newly synthesized P. aeruginosa quorum-sensing autoinducer analogs (AIA-1, -2) on the activity of azithromycin and clarithromycin against P. aeruginosa. In the killing assay of planktonic cells, AIA-1 and -2 enhanced the bactericidal ability of macrolides against P. aeruginosa PAO1; however, they did not affect the minimum inhibitory concentrations of macrolides. In addition, AIA-1 and -2 considerably improved the killing activity of azithromycin and clarithromycin in biofilm cells. The results indicated that AIA-1 and -2 could affect antibiotic tolerance. Moreover, the results of hydrocarbon adherence and cell membrane permeability assays suggested that AIA-1 and -2 changed bacterial cell surface hydrophobicity and accelerated the outer membrane permeability of the hydrophobic antibiotics such as azithromycin and clarithromycin. Our study demonstrated that the new combination therapy of macrolides and AIA-1 and -2 may improve the therapeutic efficacy of macrolides in the treatment of chronic P. aeruginosa biofilm infections. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Pseudomonas aeruginosa |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
autoinducer analog |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
macrolide |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
antibiotic tolerance |
| 書誌情報 |
en : Antibiotics
巻 11,
号 1,
p. 10,
発行日 2021-12-22
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
20796382 |
| 出版者 |
|
|
出版者 |
MDPI |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| EID |
|
|
識別子 |
383520 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
anti_11_1_10.pdf (13 MB)
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