| Item type |
文献 / Documents(1) |
| 公開日 |
2022-07-14 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
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|
関連識別子 |
https://doi.org/10.3389/fphar.2022.745020 |
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|
関連名称 |
10.3389/fphar.2022.745020 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Conditioned Medium From the Stem Cells of Human Exfoliated Deciduous Teeth Ameliorates Neuropathic Pain in a Partial Sciatic Nerve Ligation Model |
| タイトル別表記 |
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|
その他のタイトル |
SHED-CM Ameliorates Neuropathic Pain |
| 著者 |
Liu, Yao
加納, 史也
橋本, 登
Xia, Linze
Zhou, Qiao
Feng, Xingmei
ヒビ, ヒデハル
宮嵜, 彩
岩本, 勉
松香, 芳三
Zhang, Zhijun
田中, 栄二
山本, 朗仁
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| 抄録 |
|
|
内容記述 |
In neuropathic pain (NP), injury or diseases of the somatosensory system often result in highly debilitating chronic pain. Currently, there is no effective drug for the complete and definitive treatment of NP. We investigated the therapeutic potential of conditioned medium (CM) derived from stem cells from human exfoliated deciduous teeth (SHED-CM) against NP using a mouse partial sciatic nerve ligation (PSL) model. Abnormal pain sensation, such as tactile allodynia and hyperalgesia, can be caused by PSL. In the behavioral test, intravenous administration of SHED-CM greatly improved the PSL-induced hypersensitivity. We found that treatment with SHED-CM resulted in the recruitment of M2 macrophages in the injured sciatic nerve and ipsilateral L4/L5 dorsal root ganglion and suppressed microglial activation in the spinal cord. Notably, specific depletion of the anti-inflammatory M2 macrophages by mannosylated-Clodrosome markedly reduced the antinociceptive effect of SHED-CM. Intravenous administration of CM from M2 induced by SHED-CM (M2-CM) ameliorated the PSL-induced hypersensitivity. We found that M2-CM directly suppressed the expression of nociceptive receptors as well as proinflammatory mediators in Schwann cells. Taken together, our data suggest that SHED-CM ameliorates NP through the induction of the analgesic anti-inflammatory M2 macrophages. Thus, SHED-CM may be a novel therapeutic candidate for NP. |
| キーワード |
|
|
主題 |
neuropathic pain |
| キーワード |
|
|
主題 |
dental pulp stem cells |
| キーワード |
|
|
主題 |
macrophage |
| キーワード |
|
|
主題 |
MCP-1 |
| キーワード |
|
|
主題 |
siglec-9 |
| キーワード |
|
|
主題 |
conditioned medium |
| 書誌情報 |
en : Frontiers in Pharmacology
巻 13,
p. 745020,
発行日 2022-03-31
|
| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
16639812 |
| 出版者 |
|
|
出版者 |
Frontiers Media SA |
| 権利情報 |
|
|
権利情報 |
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| EID |
|
|
識別子 |
386834 |
| 言語 |
|
|
言語 |
eng |
fphar_13_745020.pdf (5.32 MB)
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