| Item type |
文献 / Documents(1) |
| 公開日 |
2022-07-22 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1172/jci.insight.152611 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1172/jci.insight.152611 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Group IIA secreted phospholipase A2 controls skin carcinogenesis and psoriasis by shaping the gut microbiota |
|
言語 |
en |
| 著者 |
ミキ, ヨシミ
タケトミ, ヨシタカ
キドグチ, ユウ
山本, 圭
ムラマツ, カズアキ
ニシトウ, ヤスマサ
Park, Jonguk
ホソミ, コウジ
ミズグチ, ケンジ
クニサワ, ジュン
ソガ, トモヨシ
Boilard, Eric
Gowda, Siddabasave Gowda B.
イケダ, カズタカ
アリタ, マコト
ムラカミ, マコト
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Besides promoting inflammation by mobilizing lipid mediators, group IIA secreted phospholipase A2 (sPLA2-IIA) prevents bacterial infection by degrading bacterial membranes. Here, we show that, despite the restricted intestinal expression of sPLA2-IIA in BALB/c mice, its genetic deletion leads to amelioration of cancer and exacerbation of psoriasis in distal skin. Intestinal expression of sPLA2-IIA is reduced after treatment with antibiotics or under germ-free conditions, suggesting its upregulation by gut microbiota. Metagenome, transcriptome, and metabolome analyses have revealed that sPLA2-IIA deficiency alters the gut microbiota, accompanied by notable changes in the intestinal expression of genes related to immunity and metabolism, as well as in the levels of various blood metabolites and fecal bacterial lipids, suggesting that sPLA2-IIA contributes to shaping of the gut microbiota. The skin phenotypes in Pla2g2a–/– mice are lost (a) when they are cohoused with littermate WT mice, resulting in the mixing of the microbiota between the genotypes, or (b) when they are housed in a more stringent pathogen-free facility, where Pla2g2a expression in WT mice is low and the gut microbial compositions in both genotypes are nearly identical. Thus, our results highlight a potentially new aspect of sPLA2-IIA as a modulator of gut microbiota, perturbation of which affects distal skin responses. |
|
言語 |
en |
| 書誌情報 |
en : JCI Insight
巻 7,
号 2,
p. e152611,
発行日 2022-01-25
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
23793708 |
| 出版者 |
|
|
出版者 |
American Society for Clinical Investigation |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is an open access article published under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/). |
| EID |
|
|
識別子 |
384004 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
jci_7_2_e152611.pdf (7.13 MB)
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