| Item type |
文献 / Documents(1) |
| 公開日 |
2022-07-26 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.1248/bpb.b21-00714 |
|
|
関連名称 |
10.1248/bpb.b21-00714 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Effective Anticancer Therapy by Combination of Nanoparticles Encapsulating Chemotherapeutic Agents and Weak Electric Current |
| 著者 |
Khatun, Anowara
Hasan, Mahadi
El-Emam, Mahran Mohamed Abd
福田, 達也
ミムラ, ミユキ
タシマ, リホ
米田, 晋太朗
ヨシミ, シンタロウ
小暮, 健太朗
|
| 抄録 |
|
|
内容記述 |
Delivery of medicines using nanoparticles via the enhanced permeability and retention (EPR) effect is a common strategy for anticancer chemotherapy. However, the extensive heterogeneity of tumors affects the applicability of the EPR effect, which needs to overcome for effective anticancer therapy. Previously, we succeeded in the noninvasive transdermal delivery of nanoparticles by weak electric current (WEC) and confirmed that WEC regulates the intercellular junctions in the skin by activating cell signaling pathways (J. Biol. Chem., 289, 2014, Hama et al.). In this study, we applied WEC to tumors and investigated the EPR effect with polyethylene glycol (PEG)-modified doxorubicin (DOX) encapsulated nanoparticles (DOX-NP) administered via intravenous injection into melanoma-bearing mice. The application of WEC resulted in a 2.3-fold higher intratumor accumulation of nanoparticles. WEC decreased the amount of connexin 43 in tumors while increasing its phosphorylation; therefore, the enhancing of intratumor delivery of DOX-NP is likely due to the opening of gap junctions. Furthermore, WEC combined with DOX-NP induced a significant suppression of tumor growth, which was stronger than with DOX-NP alone. In addition, WEC alone showed tumor growth inhibition, although it was not significant compared with non-treated group. These results are the first to demonstrate that effective anticancer therapy by combination of nanoparticles encapsulating chemotherapeutic agents and WEC. |
| キーワード |
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|
主題 |
weak electric current |
| キーワード |
|
|
主題 |
enhanced permeability and retention effect |
| キーワード |
|
|
主題 |
nanoparticle |
| キーワード |
|
|
主題 |
anticancer therapy |
| 書誌情報 |
en : Biological and Pharmaceutical Bulletin
巻 45,
号 2,
p. 194-199,
発行日 2022-02-01
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13475215 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11696048 |
| 出版者 |
|
|
出版者 |
The Pharmaceutical Society of Japan |
| EID |
|
|
識別子 |
386960 |
| 言語 |
|
|
言語 |
eng |
bpb_45_2_194.pdf (4.2 MB)
