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Enhancement of cerebroprotective effects of lipid nanoparticles encapsulating FK506 on cerebral ischemia/reperfusion injury by particle size regulation
https://tokushima-u.repo.nii.ac.jp/records/2010079
https://tokushima-u.repo.nii.ac.jp/records/2010079dd4dc524-12bc-4800-97a7-cd72e71adbfa
| 名前 / ファイル | ライセンス | アクション |
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bbrc_611_53.pdf (689 KB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||
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| 公開日 | 2022-07-26 | |||||||||||||||||||||||
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| アクセス権 | open access | |||||||||||||||||||||||
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| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1016/j.bbrc.2022.04.080 | |||||||||||||||||||||||
| 関連名称 | 10.1016/j.bbrc.2022.04.080 | |||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | Enhancement of cerebroprotective effects of lipid nanoparticles encapsulating FK506 on cerebral ischemia/reperfusion injury by particle size regulation | |||||||||||||||||||||||
| 著者 |
米田, 晋太朗
× 米田, 晋太朗
WEKO
1409
× 福田, 達也× 大園, 瑞音
WEKO
1435
× 小暮, 健太朗
WEKO
1139
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| 内容記述 | Delivery of cerebroprotective agents using liposomes has been demonstrated to be useful for treating cerebral ischemia/reperfusion (I/R) injury. We previously reported that intravenous administration of liposomes with diameters of 100 nm showed higher accumulation in the I/R region compared with larger liposomes (>200 nm) by passage through the disintegrated blood-brain barrier, suggesting a size-dependence for liposome-mediated drug delivery. Based on these findings, we hypothesized that regulation of liposomal particle size (<100 nm) may enhance the therapeutic efficacy of encapsulated drugs on cerebral I/R injury. Herein, we prepared lipid nanoparticles (LNP) with particle sizes <100 nm by the microfluidics method and compared their therapeutic potential with LNP exhibiting sizes >100 nm in cerebral I/R model rats. Intravenously administered smaller LNP (ca. 60 nm) exhibited wider accumulation and diffusivity in the brain parenchyma of the I/R region compared with larger LNP (>100 nm). Importantly, treatment with LNP encapsulating the cerebroprotective agent FK506 (FK-LNP) with particle sizes <100 nm showed greater cerebroprotective effects than FK-LNP with sizes >100 nm, and also significantly ameliorated brain injury. These results suggest that particle size regulation of LNP to sizes <100 nm can enhance the therapeutic effect of encapsulated drugs for treatment of cerebral I/R injury, and that FK-LNP could be a promising cerebroprotective agent. | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | Cerebral ischemia/reperfusion injury | |||||||||||||||||||||||
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| 主題 | Blood-brain barrier | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | Lipid nanoparticles | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | Particle size regulation | |||||||||||||||||||||||
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| 主題 | Microfluidics | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | FK506 | |||||||||||||||||||||||
| 書誌情報 |
en : Biochemical and Biophysical Research Communications 巻 611, p. 53-59, 発行日 2022-04-21 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 0006291X | |||||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||||
| 収録物識別子 | AA00564395 | |||||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||||
| 収録物識別子 | AA11542044 | |||||||||||||||||||||||
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| 出版者 | Elsevier | |||||||||||||||||||||||
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| 権利情報 | © 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||||||||||||||||||
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| 識別子 | 386964 | |||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||
