| Item type |
文献 / Documents(1) |
| 公開日 |
2022-07-28 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.3390/ijms22168992 |
|
|
関連名称 |
10.3390/ijms22168992 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Macrophage Motility in Wound Healing Is Regulated by HIF-1α via S1P Signaling |
| 著者 |
Hutami, Islamy Rahma
井澤, 俊
Khurel‐Ochir, Tsendsuren
坂巻, 拓馬
岩浅, 亮彦
田中, 栄二
|
| 抄録 |
|
|
内容記述 |
Accumulating evidence indicates that the molecular pathways mediating wound healing induce cell migration and localization of cytokines to sites of injury. Macrophages are immune cells that sense and actively respond to disturbances in tissue homeostasis by initiating, and subsequently resolving, inflammation. Hypoxic conditions generated at a wound site also strongly recruit macrophages and affect their function. Hypoxia inducible factor (HIF)-1α is a transcription factor that contributes to both glycolysis and the induction of inflammatory genes, while also being critical for macrophage activation. For the latter, HIF-1α regulates sphingosine 1-phosphate (S1P) to affect the migration, activation, differentiation, and polarization of macrophages. Recently, S1P and HIF-1α have received much attention, and various studies have been performed to investigate their roles in initiating and resolving inflammation via macrophages. It is hypothesized that the HIF-1α/S1P/S1P receptor axis is an important determinant of macrophage function under inflammatory conditions and during disease pathogenesis. Therefore, in this review, biological regulation of monocytes/macrophages in response to circulating HIF-1α is summarized, including signaling by S1P/S1P receptors, which have essential roles in wound healing. |
| キーワード |
|
|
主題 |
HIF1 |
| キーワード |
|
|
主題 |
M1/M2 macrophage |
| キーワード |
|
|
主題 |
S1P |
| キーワード |
|
|
主題 |
wound healing |
| 書誌情報 |
en : International Journal of Molecular Sciences
巻 22,
号 16,
p. 8992,
発行日 2021-08-20
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
14220067 |
| 出版者 |
|
|
出版者 |
MDPI |
| 権利情報 |
|
|
権利情報 |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| EID |
|
|
識別子 |
386795 |
| 言語 |
|
|
言語 |
eng |
ijms_22_16_8992.pdf (1.05 MB)
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