| Item type |
文献 / Documents(1) |
| 公開日 |
2022-08-23 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_db06 |
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資源タイプ |
doctoral thesis |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1111/cts.13282 |
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関連名称 |
10.1111/cts.13282 |
| 出版タイプ |
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出版タイプ |
NA |
|
出版タイプResource |
http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
| タイトル |
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|
タイトル |
Discovery of preventive drugs for cisplatin-induced acute kidney injury using big data analysis |
| タイトル別表記 |
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その他のタイトル |
ビッグデータ解析を用いたシスプラチン誘発急性腎障害に対する予防薬の探索 |
| タイトル別表記 |
|
|
その他のタイトル |
DISCOVERY OF PREVENTIVE DRUGS FOR CDDP-INDUCED AKI |
| 著者 |
神田, 将哉
合田, 光寛
マエガワ, アキコ
ヨシオカ, トシヒコ
ヨシダ, アミ
ミヤタ, コウジ
相澤, 風花
新村, 貴博
濱野, 裕章
岡田, 直人
サクラダ, タクミ
中馬, 真幸
八木, 健太
(井澤)石澤, 有紀
楊河, 宏章
座間味, 義人
石澤, 啓介
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| 抄録 |
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内容記述 |
Cisplatin is effective against many types of carcinoma. However, a high rate of renal damage is a clinical problem. Thus, there is a need to establish a method to prevent it. Although various compounds have been reported to be effective against cisplatin-induced renal injury, there are no examples of their clinical application. Therefore, we attempted to search for prophylactic agents with a high potential for clinical application. We used Cascade Eye to identify genes that are altered during cisplatin-induced renal injury, Library of Integrated Network-based Cellular Signatures (LINCS) to identify drugs that inhibit changes in gene expression, and a large database of spontaneous adverse drug reaction reports to identify drugs that could prevent cisplatin-induced kidney injury in clinical practice. In total, 10 candidate drugs were identified. Using the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS), we identified drugs that reduce cisplatin-induced kidney injury. Fenofibrate was selected as a candidate drug to prevent cisplatin-induced kidney injury based on the FAERS analysis. A model was used to evaluate the efficacy of fenofibrate against cisplatin-induced renal injury. Studies using HK2 cells and mouse models showed that fenofibrate significantly inhibited cisplatin-induced renal injury but did not inhibit the antitumor effect of cisplatin. Fenofibrate is a candidate prophylactic drug with high clinical applicability for cisplatin-induced renal injury. Analysis of data from multiple big databases will improve the search for novel prophylactic drugs with high clinical applicability. For the practical application of these findings, evaluation in prospective controlled trials is necessary. |
| キーワード |
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|
主題 |
pharmacology |
| キーワード |
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|
主題 |
adverse drug reaction |
| キーワード |
|
|
主題 |
cancer |
| キーワード |
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|
主題 |
fenofibrate |
| キーワード |
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|
主題 |
cisplatin |
| キーワード |
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|
主題 |
renal injury |
| 書誌情報 |
en : Clinical and Translational Science
巻 15,
号 7,
p. 1664-1675,
発行日 2022-04-20
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
17528062 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12625737 |
| 出版者 |
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出版者 |
Wiley |
| 出版者 |
|
|
出版者 |
American Society for Clinical Pharmacology and Therapeutics |
| 備考 |
|
|
値 |
内容要旨・審査要旨・論文本文の公開
本論文は，著者Masaya Kandaの学位論文として提出され，学位審査・授与の対象となっている。
学位授与者所属 : 徳島大学大学院医学研究科（医学専攻） |
| 権利情報 |
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権利情報 |
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| EID |
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識別子 |
390280 |
| 言語 |
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言語 |
eng |
| 報告番号 |
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|
学位授与番号 |
甲第3648号 |
| 学位記番号 |
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|
値 |
甲医第1539号 |
| 学位授与年月日 |
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学位授与年月日 |
2022-09-08 |
| 学位名 |
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|
学位名 |
博士（医学） |
| 学位授与機関 |
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|
学位授与機関名 |
徳島大学 |
k3648_abstract.pdf (109 KB)
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