| Item type |
文献 / Documents(1) |
| 公開日 |
2022-09-05 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.5551/jat.63118 |
|
|
言語 |
ja |
|
|
関連名称 |
10.5551/jat.63118 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Non-High-Density Lipoprotein Cholesterol and Risk of Cardiovascular Disease : The Japan Epidemiology Collaboration on Occupational Health Study |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
Non-HDL-C and CVD |
|
言語 |
en |
| 著者 |
Hu, Huan
フクナガ, アミ
ヨコヤ, トシタカ
ナカガワ, トオル
ホンダ, トオル
ヤマモト, シュウイチロウ
オカザキ, ヒロコ
ミヤモト, トシアキ
ササキ, ナオコ
オガサワラ, タカユキ
ゴンモリ, ナオキ
ヤマモト, ケンヤ
ホリ, アイ
トミタ, ケンタロウ
ナガハマ, サツエ
コニシ, マキ
カタヤマ, ノブミ
森岡, 久尚
カベ, イサム
ミゾウエ, テツヤ
ドヒ, セイタロウ
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Aims: We aimed to investigate the association between non-high-density lipoprotein cholesterol (non-HDL-C) levels and the risk of cardiovascular disease (CVD) and its subtypes.
Methods: In this contemporary cohort study, we analyzed the data of 63,814 Japanese employees aged ≥ 30 years, without known CVD in 2012 and who were followed up for up to 8 years. The non-HDL-C level was divided into 5 groups: ＜110, 110-129, 130-149, 150-169, and ≥ 170 mg/dL. The Cox proportional hazards model was used to calculate the hazard ratios (HRs) and the corresponding 95% confidence intervals (CIs) for CVD and its subtypes associated with each non-HDL-C group, considering 130-149 mg/dL as the reference group.
Results: During the study period, 271 participants developed CVD, including 78 myocardial infarctions and 193 strokes (102 ischemic strokes, 89 hemorrhagic strokes, and 2 unknowns). A U-shaped association between non-HDL-C and stroke was observed. In the analysis of stroke subtypes, the multivariable-adjusted HR (95% CI) for hemorrhagic stroke was 2.61 (1.19–5.72), 2.02 (0.95–4.29), 2.10 (1.01–4.36), and 1.98 (0.96-4.08), while that for ischemic stroke was 1.54 (0.77-3.07), 0.91 (0.46-1.80), 0.73 (0.38-1.41), and 1.50 (0.87-2.56) in the ＜110, 110-129, 150-169, and ≥ 170 mg/dL groups, respectively. Individuals with elevated non-HDL-C levels had a higher risk of myocardial infarction.
Conclusions: High non-HDL-C levels were associated with an increased risk of myocardial infarction. Moreover, high and low non-HDL-C levels were associated with a high risk of stroke and its subtypes among Japanese workers. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Non-high-density lipoprotein cholesterol |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Stroke |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Myocardial infarction |
| 書誌情報 |
en : Journal of Atherosclerosis and Thrombosis
巻 29,
号 9,
p. 1295-1306,
発行日 2021-09-01
|
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
18803873 |
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13403478 |
| 出版者 |
|
|
出版者 |
Japan Atherosclerosis Society |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License. |
| EID |
|
|
識別子 |
388649 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
jat_29_9_1295.pdf (166 KB)
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