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Semaphorin 3A : A potential target for prevention and treatment of nickel allergy
https://tokushima-u.repo.nii.ac.jp/records/2010252
https://tokushima-u.repo.nii.ac.jp/records/2010252f045ce35-a12d-4eaf-ae5f-bed56d2e0fac
| 名前 / ファイル | ライセンス | アクション |
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cb_5_671.pdf (3.73 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||||
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| 公開日 | 2022-09-12 | |||||||||||||||||||||||||
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| アクセス権 | open access | |||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1038/s42003-022-03641-0 | |||||||||||||||||||||||||
| 関連名称 | 10.1038/s42003-022-03641-0 | |||||||||||||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||||
| タイトル | Semaphorin 3A : A potential target for prevention and treatment of nickel allergy | |||||||||||||||||||||||||
| 著者 |
劉, 黎佩
× 劉, 黎佩
× 渡邉, 恵
WEKO
1260
× 南, 憲一× Yunizar, Mohammad Fadyl
× 市川, 哲雄
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1652
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| 内容記述 | Metal allergy is one of the typical immune disorders encountered during the application of dental/medical materials and has a highly complex pathogenic mechanism. Semaphorin 3A (Sema3A), a member of the semaphorin family, is reported to be involved in various immune disorders. However, its role in metal allergy has not been clarified yet. Herein, we show that Sema3A expression was upregulated in nickel (Ni) allergy-induced mouse ear tissue and in NiCl2-stimulated mouse keratinocytes. Moreover, Sema3A regulated tumor necrosis factor-alpha production and mitogen-activated protein kinase activation in keratinocytes. The specific deletion of Sema3A in keratinocytes did not affect immune cell infiltration but reduced edema and ear swelling; it also impeded Th1 responses to cause a slight alleviation in Ni allergy in mice. Our results demonstrate that Sema3A promotes the development of metal allergy and should be explored as a potential target for the prevention and treatment of metal allergy. | |||||||||||||||||||||||||
| 書誌情報 |
en : Communications Biology 巻 5, p. 671, 発行日 2022-07-07 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||||
| 収録物識別子 | 23993642 | |||||||||||||||||||||||||
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| 出版者 | Springer Nature | |||||||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||||||
| 権利情報 | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | |||||||||||||||||||||||||
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| 識別子 | 387597 | |||||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||||
