| Item type |
文献 / Documents(1) |
| 公開日 |
2022-09-20 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1002/fsn3.2733 |
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関連名称 |
10.1002/fsn3.2733 |
| 出版タイプ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
8-Prenylnaringenin tissue distribution and pharmacokinetics in mice and its binding to human serum albumin and cellular uptake in human embryonic kidney cells |
| 著者 |
タナカ, ヨシアキ
オクヤマ, ヒトミ
ニシカワ, ミユ
イクシロ, シンイチ
イケダ, マユミ
異島, 優
ウカワ, ユウイチ
オオエ, ケンイチ
寺尾, 純二
向井, 理恵
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| 抄録 |
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内容記述 |
8-Prenylnaringenin (8-PN), a hop flavonoid, is a promising food substance with health benefits. Compared with nonprenylated naringenin, 8-PN exhibits stronger estrogenic activity and prevents muscle atrophy. Moreover, 8-PN prevents hot flushes and bone loss. Considering that prenylation reportedly improves the bioavailability of flavonoids, we compared the parameters related to the bioavailability [pharmacokinetics and tissue distribution in C57/BL6 mice, binding affinity to human serum albumin (HSA), and cellular uptake in HEK293 cells] of 8-PN and its mother (non-prenylated) compound naringenin. C57/BL6 mice were fed an 8-PN or naringenin mixed diet for 22 days. The amount of 8-PN (nmol/g tissue) in the kidneys (16.8 ± 9.20), liver (14.8 ± 2.58), muscles (3.33 ± 0.60), lungs (2.07 ± 0.68), pancreas (1.80 ± 0.38), heart (1.71 ± 0.27), spleen (1.36 ± 0.29), and brain (0.31 ± 0.09) was higher than that of naringenin. A pharmacokinetic study in mice demonstrated that the Cmax of 8-PN (50 mg/kg body weight) was lower than that of naringenin; however, the plasma concentration of 8-PN 8 h after ingestion was higher than that of naringenin. The binding affinity of 8-PN to HSA and cellular uptake in HEK293 cells were higher than those of naringenin. 8-PN bioavailability features assessed in mouse or human model experiments were obviously different from those of naringenin. |
| キーワード |
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|
主題 |
8-prenylnaringenin |
| キーワード |
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|
主題 |
naringenin |
| キーワード |
|
|
主題 |
pharmacokinetics |
| キーワード |
|
|
主題 |
serum albumin |
| キーワード |
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|
主題 |
tissue accumulation |
| 書誌情報 |
en : Food Science & Nutrition
巻 10,
号 4,
p. 1070-1080,
発行日 2022-01-22
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
20487177 |
| 出版者 |
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出版者 |
Wiley Periodicals |
| 権利情報 |
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|
権利情報 |
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| EID |
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|
識別子 |
391150 |
| 言語 |
|
|
言語 |
eng |
fsn_10_4_1070.pdf (499 KB)
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