| Item type |
文献 / Documents(1) |
| 公開日 |
2022-09-28 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.4049/jimmunol.2100692 |
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関連名称 |
10.4049/jimmunol.2100692 |
| 出版タイプ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Aire Controls Heterogeneity of Medullary Thymic Epithelial Cells for the Expression of Self-Antigens |
| タイトル別表記 |
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その他のタイトル |
A NEW LOOK AT TRANSCRIPTIONAL REGULATION BY AIRE IN mTECs |
| 著者 |
西嶋, 仁
松本, 穣
森本, 純子
ホソミチ, カズヨシ
アキヤマ, ノブコ
アキヤマ, タイシン
尾矢, 剛志
常山, 幸一
ヨシダ, ヒデユキ
松本, 満
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| 抄録 |
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内容記述 |
The deficiency of Aire, a transcriptional regulator whose defect results in the development of autoimmunity, is associated with reduced expression of tissue-restricted self-Ags (TRAs) in medullary thymic epithelial cells (mTECs). Although the mechanisms underlying Aire-dependent expression of TRAs need to be explored, the physical identification of the target(s) of Aire has been hampered by the low and promiscuous expression of TRAs. We have tackled this issue by engineering mice with augmented Aire expression. Integration of the transcriptomic data from Aire-augmented and Aire-deficient mTECs revealed that a large proportion of so-called Aire-dependent genes, including those of TRAs, may not be direct transcriptional targets downstream of Aire. Rather, Aire induces TRA expression indirectly through controlling the heterogeneity of mTECs, as revealed by single-cell analyses. In contrast, Ccl25 emerged as a canonical target of Aire, and we verified this both in vitro and in vivo. Our approach has illuminated the Aire’s primary targets while distinguishing them from the secondary targets. |
| 書誌情報 |
en : The Journal of Immunology
巻 208,
号 2,
p. 303-320,
発行日 2022-01-11
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
15506606 |
| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
00221767 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12067070 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00699656 |
| 出版者 |
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|
出版者 |
The American Association of Immunologists |
| 権利情報 |
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|
権利情報 |
This article is distributed under The American Association of Immunologists, Inc.,
Reuse Terms and Conditions for Author Choice articles (https://www.jimmunol.org/info/authorchoice). |
| EID |
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|
識別子 |
384533 |
| 言語 |
|
|
言語 |
eng |
jimmunol_208_2_303.pdf (4.24 MB)
