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Development of Mucosal Vaccines as Novel Preventive Methods against Infectious and Noncommunicable Diseases (NCDs) : Contribution to a Society of Health and Longevity
https://tokushima-u.repo.nii.ac.jp/records/2010310
https://tokushima-u.repo.nii.ac.jp/records/201031021bc4d10-54b8-4c99-8a75-6eb93b34a7ef
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
johb_35_1_27.pdf (2.27 MB)
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| Item type | 文献 / Documents(1) | |||||||||||
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| 公開日 | 2022-09-27 | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| 出版社版DOI | ||||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | https://doi.org/10.20738/johb.35.1_27 | |||||||||||
| 言語 | ja | |||||||||||
| 関連名称 | 10.20738/johb.35.1_27 | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Development of Mucosal Vaccines as Novel Preventive Methods against Infectious and Noncommunicable Diseases (NCDs) : Contribution to a Society of Health and Longevity | |||||||||||
| 言語 | en | |||||||||||
| タイトル別表記 | ||||||||||||
| その他のタイトル | Dendritic Cells-targeting Nasal Adjuvant | |||||||||||
| 言語 | en | |||||||||||
| 著者 |
片岡, 宏介
× 片岡, 宏介
WEKO
300
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| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | The surface layer of the mucosa, which in adult humans, is estimated to have a surface area over 200 times greater than that of the skin, is constantly in contact with foreign antigens, against which non-specific defense (innate immune mechanisms) and specific defense (acquired immune mechanisms) are activated. In the mucosal areas that are the entry points for foreign antigens, the efficient production and secretion of secretory IgA (SIgA) antibodies, which are the main form of specific defense, and mucosal vaccines, which are an efficient antigen delivery system for inducing and promoting antibody production, may offer a strategic tool for preventing not only infections, but also the development of lifestyle-related diseases. We have previously undertaken research and development of an immunostimulating agent (adjuvant) for use with mucosal vaccines based on mucosal immunity, particularly nasal vaccines that are administered to the nasal cavity. More specifically, a double DNA adjuvant (dDA) system that targets dendritic cells, which are one of antigen-presenting cells, was developed, and basic research was conducted using a number of different antigens, including a comparison of the immune response to these antigens when they were introduced into the nasal cavities of young and old experimental animals (mice). Of late, we have been working toward the development of a mucosal vaccine capable of preventing infection or lifestyle-related disease that can also be used in older people. In this review article, I will introduce the advantages of mucosal vaccines as well as recent findings in our group. | |||||||||||
| 言語 | en | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Nasal vaccine | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | DNA Adjuvant | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | double DNA adjuvant (dDA) | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Dendritic cells | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Prevention of infectious and noncommunicable diseases | |||||||||||
| 書誌情報 |
en : Journal of Oral Health and Biosciences 巻 35, 号 1, p. 27-32, 発行日 2022-09-14 |
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| 収録物ID | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 21896682 | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | 四国歯学会 | |||||||||||
| 言語 | ja | |||||||||||
| EID | ||||||||||||
| 識別子 | 392035 | |||||||||||
| 識別子タイプ | URI | |||||||||||
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| 言語 | eng | |||||||||||
