| Item type |
文献 / Documents(1) |
| 公開日 |
2022-12-02 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
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|
関連識別子 |
https://doi.org/10.3390/jcm10040614 |
|
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関連名称 |
10.3390/jcm10040614 |
| 出版タイプ |
|
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Urinary Titin N-Fragment as a Biomarker of Muscle Atrophy, Intensive Care Unit-Acquired Weakness, and Possible Application for Post-Intensive Care Syndrome |
| 著者 |
中西, 信人
堤, 理恵
ハラ, カナコ
マツオ, マサフミ
阪上, 浩
大藤, 純
|
| 抄録 |
|
|
内容記述 |
Titin is a giant protein that functions as a molecular spring in sarcomeres. Titin interconnects the contraction of actin-containing thin filaments and myosin-containing thick filaments. Titin breaks down to form urinary titin N-fragments, which are measurable in urine. Urinary titin N-fragment was originally reported to be a useful biomarker in the diagnosis of muscle dystrophy. Recently, the urinary titin N-fragment has been increasingly gaining attention as a novel biomarker of muscle atrophy and intensive care unit-acquired weakness in critically ill patients, in whom titin loss is a possible pathophysiology. Furthermore, several studies have reported that the urinary titin N-fragment also reflected muscle atrophy and weakness in patients with chronic illnesses. It may be used to predict the risk of post-intensive care syndrome or to monitor patients’ condition after hospital discharge for better nutritional and rehabilitation management. We provide several tips on the use of this promising biomarker in post-intensive care syndrome. |
| キーワード |
|
|
主題 |
titin |
| キーワード |
|
|
主題 |
muscle |
| キーワード |
|
|
主題 |
diaphragm |
| キーワード |
|
|
主題 |
atrophy |
| キーワード |
|
|
主題 |
physical dysfunction |
| キーワード |
|
|
主題 |
biomarker |
| キーワード |
|
|
主題 |
urine |
| キーワード |
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|
主題 |
post-intensive care syndrome |
| キーワード |
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|
主題 |
nutrition |
| キーワード |
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|
主題 |
rehabilitation |
| 書誌情報 |
en : Journal of Clinical Medicine
巻 10,
号 4,
p. 614,
発行日 2021-02-06
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
20770383 |
| 出版者 |
|
|
出版者 |
MDPI |
| 権利情報 |
|
|
権利情報 |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| EID |
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|
識別子 |
389388 |
| 言語 |
|
|
言語 |
eng |
jcm_10_4_614.pdf (1.01 MB)
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