| Item type |
文献 / Documents(1) |
| 公開日 |
2022-12-09 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.3390/molecules27041425 |
|
|
関連名称 |
10.3390/molecules27041425 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Tocopheryl Phosphate Inhibits Rheumatoid Arthritis-Related Gene Expression In Vitro and Ameliorates Arthritic Symptoms in Mice |
| 著者 |
ハマ, ススム
キリムラ, ナオコ
オバラ, アキ
タカツ, ヒロカツ
小暮, 健太朗
|
| 抄録 |
|
|
内容記述 |
Anti-rheumatoid arthritis (RA) effects of α-tocopherol (α-T) have been shown in human patients in a double-blind trial. However, the effects of α-T and its derivatives on fibroblast-like synoviocytes (FLS) during the pathogenesis of RA remain unclear. In the present study, we compared the expression levels of genes related to RA progression in FLS treated with α-T, succinic ester of α-T (TS), and phosphate ester of α-T (TP), as determined via RT-PCR. The mRNA levels of interleukin (IL)-6, tumor necrosis factor-α (TNF-α), matrix metalloproteinase (MMP)-3, and MMP-13 were reduced by treatment with TP without cytotoxicity, while α-T and TS did not show such effects. Furthermore, intraperitoneal injection of TP ameliorated the edema of the foot and joint and improved the arthritis score in laminarin-induced RA model mice. Therefore, TP exerted anti-RA effects through by inhibiting RA-related gene expression. |
| キーワード |
|
|
主題 |
α-tocopherol |
| キーワード |
|
|
主題 |
tocopheryl phosphate |
| キーワード |
|
|
主題 |
tocopheryl succinate |
| キーワード |
|
|
主題 |
rheumatoid arthritis |
| 書誌情報 |
en : Molecules
巻 27,
号 4,
p. 1425,
発行日 2022-02-20
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
14203049 |
| 出版者 |
|
|
出版者 |
MDPI |
| 権利情報 |
|
|
権利情報 |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| EID |
|
|
識別子 |
386962 |
| 言語 |
|
|
言語 |
eng |
molecules_27_4_1425.pdf (3.05 MB)
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