| Item type |
文献 / Documents(1) |
| 公開日 |
2022-10-18 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.1248/bpb.b21-00745 |
|
|
関連名称 |
10.1248/bpb.b21-00745 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
A Genome-Wide Association Study Predicts the Onset of Dysgeusia Due to Anti-cancer Drug Treatment |
| 著者 |
タケイ, ミノリ
岡田, 直人
中村, 信元
賀川, 久美子
藤井, 志朗
三木, 浩和
石澤, 啓介
安倍, 正博
佐藤, 陽一
|
| 抄録 |
|
|
内容記述 |
Dysgeusia is a major side effect of anti-cancer drug treatment. Since dysgeusia significantly lowers the patient’s QOL, predicting and avoiding its onset in advance is desirable. Accordingly, aims of the present study were to use a genome-wide association study (GWAS) to identify genes associated with the development of dysgeusia in patients taking anti-cancer drugs and to predict the development of dysgeusia using associated single nucleotide polymorphisms (SNPs). GWAS was conducted on 76 patients admitted to the Department of Hematology, Tokushima University Hospital. Using Sanger sequencing for 23 separately collected validation samples, the top two SNPs associated with the development of dysgeusia were determined. GWAS identified rs73049478 and rs41396146 SNPs on the retinoic acid receptor beta (RARB) gene associated with dysgeusia development due to the administration of anti-cancer drugs. Evaluation of the two SNPs using 23 validation samples indicated that the accuracy rate of rs73049478 was relatively high (87.0%). Thus, the findings of the present study suggest that the rs73049478 SNP of RARB can be used to predict the onset of dysgeusia caused by the administration of anti-cancer drugs. |
| キーワード |
|
|
主題 |
genome-wide association study |
| キーワード |
|
|
主題 |
dysgeusia |
| キーワード |
|
|
主題 |
anti-cancer drug |
| キーワード |
|
|
主題 |
hematopoietic tumor |
| キーワード |
|
|
主題 |
single nucleotide polymorphism |
| 書誌情報 |
en : Biological and Pharmaceutical Bulletin
巻 45,
号 1,
p. 114-117,
発行日 2022-01-01
|
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13475215 |
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
09186158 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11696048 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10885497 |
| 出版者 |
|
|
出版者 |
The Pharmaceutical Society of Japan |
| EID |
|
|
識別子 |
383649 |
| 言語 |
|
|
言語 |
eng |
bpb_45_1_114.pdf (466 KB)
