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Application and Utility of Liposomal Neuroprotective Agents and Biomimetic Nanoparticles for the Treatment of Ischemic Stroke
https://tokushima-u.repo.nii.ac.jp/records/2010393
https://tokushima-u.repo.nii.ac.jp/records/2010393f5fbb20f-6ab5-4997-94cb-c12d97c114fa
| 名前 / ファイル | ライセンス | アクション |
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pharm_14_2_361.pdf (2.91 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||
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| 公開日 | 2022-12-21 | |||||||||||||||||
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| アクセス権 | open access | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| 出版社版DOI | ||||||||||||||||||
| 関連識別子 | https://doi.org/10.3390/pharmaceutics14020361 | |||||||||||||||||
| 関連名称 | 10.3390/pharmaceutics14020361 | |||||||||||||||||
| 出版タイプ | ||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Application and Utility of Liposomal Neuroprotective Agents and Biomimetic Nanoparticles for the Treatment of Ischemic Stroke | |||||||||||||||||
| 著者 |
福田, 達也
× 福田, 達也× オク, ナオト
× 小暮, 健太朗
WEKO
1139
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| 内容記述 | Ischemic stroke is still one of the leading causes of high mortality and severe disability worldwide. Therapeutic options for ischemic stroke and subsequent cerebral ischemia/reperfusion injury remain limited due to challenges associated with drug permeability through the blood-brain barrier (BBB). Neuroprotectant delivery with nanoparticles, including liposomes, offers a promising solution to address this problem, as BBB disruption following ischemic stroke allows nanoparticles to pass through the intercellular gaps between endothelial cells. To ameliorate ischemic brain damage, a number of nanotherapeutics encapsulating neuroprotective agents, as well as surface-modified nanoparticles with specific ligands targeting the injured brain regions, have been developed. Combination therapy with nanoparticles encapsulating neuroprotectants and tissue plasminogen activator (t-PA), a globally approved thrombolytic agent, has been demonstrated to extend the narrow therapeutic time window of t-PA. In addition, the design of biomimetic drug delivery systems (DDS) employing circulating cells (e.g., leukocytes, platelets) with unique properties has recently been investigated to overcome the injured BBB, utilizing these cells’ inherent capability to penetrate the ischemic brain. Herein, we review recent findings on the application and utility of nanoparticle DDS, particularly liposomes, and various approaches to developing biomimetic DDS functionalized with cellular membranes/membrane proteins for the treatment of ischemic stroke. | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | nanoparticles | |||||||||||||||||
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| 主題 | liposomes | |||||||||||||||||
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| 主題 | ischemic stroke | |||||||||||||||||
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| 主題 | cerebral ischemia/reperfusion injury | |||||||||||||||||
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| 主題 | blood-brain barrier | |||||||||||||||||
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| 主題 | biomimetic DDS | |||||||||||||||||
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| 主題 | leukocytes | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | intermembrane protein transfer | |||||||||||||||||
| 書誌情報 |
en : Pharmaceutics 巻 14, 号 2, p. 361, 発行日 2022-02-04 |
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| 収録物ID | ||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 19994923 | |||||||||||||||||
| 出版者 | ||||||||||||||||||
| 出版者 | MDPI | |||||||||||||||||
| 権利情報 | ||||||||||||||||||
| 権利情報 | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | |||||||||||||||||
| EID | ||||||||||||||||||
| 識別子 | 390036 | |||||||||||||||||
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| 言語 | eng | |||||||||||||||||
