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The first non-prion pathogen identified : neurotropic influenza virus
https://tokushima-u.repo.nii.ac.jp/records/2010395
https://tokushima-u.repo.nii.ac.jp/records/2010395c0f28cd5-9d17-4209-86b9-f204fa680bca
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
prion_16_1_1.pdf (508 KB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||
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| 公開日 | 2022-12-21 | |||||||||||||||||
| アクセス権 | ||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| 出版社版DOI | ||||||||||||||||||
| 関連識別子 | https://doi.org/10.1080/19336896.2021.2015224 | |||||||||||||||||
| 関連名称 | 10.1080/19336896.2021.2015224 | |||||||||||||||||
| 出版タイプ | ||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | The first non-prion pathogen identified : neurotropic influenza virus | |||||||||||||||||
| 著者 |
坂口, 末廣
× 坂口, 末廣
WEKO
220
× 原, 英之
WEKO
557
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| 内容記述 | The cellular isoform of prion protein, designated PrPC, is a membrane glycoprotein expressed most abundantly in the brain, particularly by neurons, and its conformational conversion into the abnormally folded, amyloidogenic isoform, PrPSc, is an underlying mechanism in the pathogenesis of prion diseases, a group of neurodegenerative disorders in humans and animals. Most cases of these diseases are sporadic and their aetiologies are unknown. We recently found that a neurotropic strain of influenza A virus (IAV/WSN) caused the conversion of PrPC into PrPSc and the subsequent formation of infectious prions in mouse neuroblastoma cells after infection. These results show that IAV/WSN is the first non-prion pathogen capable of inducing the conversion of PrPC into PrPSc and propagating infectious prions in cultured neuronal cells, and also provide the intriguing possibility that IAV infection in neurons might be a cause of or be associated with sporadic prion diseases. Here, we present our findings of the IAV/WSN-induced conversion of PrPC into PrPSc and subsequent propagation of infectious prions, and also discuss the biological significance of the conversion of PrPC into PrPSc in virus infections. | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | Prion | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | prion protein | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | prion disease | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | neurodegenerative disease | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | virus infection | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | conformational conversion | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | influenza virus | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | protein polymerization | |||||||||||||||||
| 書誌情報 |
en : Prion 巻 16, 号 1, p. 1-6, 発行日 2022-01-03 |
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| 収録物ID | ||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 19336896 | |||||||||||||||||
| 収録物ID | ||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 1933690X | |||||||||||||||||
| 収録物ID | ||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||
| 収録物識別子 | AA12489843 | |||||||||||||||||
| 出版者 | ||||||||||||||||||
| 出版者 | Taylor & Francis | |||||||||||||||||
| 権利情報 | ||||||||||||||||||
| 権利情報 | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||||||||||||||
| EID | ||||||||||||||||||
| 識別子 | 388677 | |||||||||||||||||
| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
