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Development of a more accurate Geant4 quantum molecular dynamics model for hadron therapy
https://tokushima-u.repo.nii.ac.jp/records/2010399
https://tokushima-u.repo.nii.ac.jp/records/20103994277ee21-623f-4909-b9e8-2736a155e814
| 名前 / ファイル | ライセンス | アクション |
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pmb_67_22_225001.pdf (3.8 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||
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| 公開日 | 2022-10-24 | |||||||||||||||||||||||
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| アクセス権 | open access | |||||||||||||||||||||||
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| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1088/1361-6560/ac9a9a | |||||||||||||||||||||||
| 関連名称 | 10.1088/1361-6560/ac9a9a | |||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | Development of a more accurate Geant4 quantum molecular dynamics model for hadron therapy | |||||||||||||||||||||||
| タイトル別表記 | ||||||||||||||||||||||||
| その他のタイトル | Development of a more accurate Geant4 QMD model for hadron therapy | |||||||||||||||||||||||
| 著者 |
サトウ, ヨシヒデ
× サトウ, ヨシヒデ
× サカタ, ドウサツ
× Bolst, David
× Simpson, Edward C.
× Guatelli, Susanna
× 芳賀, 昭弘 |
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| 抄録 | ||||||||||||||||||||||||
| 内容記述 | Objective: Although in heavy-ion therapy, the quantum molecular dynamics (QMD) model is one of the most fundamental physics models providing an accurate daughter-ion production yield in the final state, there are still non-negligible differences with the experimental results. The aim of this study is to improve fragment production in water phantoms by developing a more accurate QMD model in Geant4. Approach: A QMD model was developed by implementing modern Skyrme interaction parameter sets, as well as by incorporating with an ad hoc α-cluster model in the initial nuclear state. Two adjusting parameters were selected that can significantly affect the fragment productions in the QMD model: the radius to discriminate a cluster to which nucleons belong after the nucleus-nucleus reaction, denoted by R, and the squared standard deviation of the Gaussian packet, denoted by L. Squared Mahalanobis’s distance of fragment yields and angular distributions with 1, 2, and the higher atomic number for the produced fragments were employed as objective functions, and multi-objective optimization (MOO), which make it possible to compare quantitatively the simulated production yields with the reference experimental data, was performed. Main results: The MOO analysis showed that the QMD model with modern Skyrme parameters coupled with the proposed α-cluster model, denoted as SkM∗α, can drastically improve light fragments yields in water. In addition, the proposed model reproduced the kinetic energy distribution of the fragments accurately. The optimized L in SkM∗α was confirmed to be realistic by the charge radii analysis in the ground state formation. Significance: The proposed framework using MOO was demonstrated to be very useful in judging the superiority of the proposed nuclear model. The optimized QMD model is expected to improve the accuracy of heavy-ion therapy dosimetry. |
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| 書誌情報 |
en : Physics in Medicine & Biology 巻 67, 号 22, p. 225001, 発行日 2022-11-04 |
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| 収録物ID | ||||||||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 00319155 | |||||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||||
| 収録物識別子 | AA12472523 | |||||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||||
| 収録物識別子 | AA00774048 | |||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||
| 出版者 | IOP Publishing | |||||||||||||||||||||||
| 備考 | ||||||||||||||||||||||||
| 値 | This is the Accepted Manuscript version of an article accepted for publication in Physics in Medicine & Biology. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at 10.1088/1361-6560/ac9a9a. | |||||||||||||||||||||||
| EID | ||||||||||||||||||||||||
| 識別子 | 392484 | |||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||
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サトウ, ヨシヒデ, サカタ, ドウサツ, Bolst, David, Simpson, Edward C., Guatelli, Susanna, 芳賀, 昭弘, 2022, Development of a more accurate Geant4 quantum molecular dynamics model for hadron therapy: IOP Publishing, 225001– p.
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