| Item type |
文献 / Documents(1) |
| 公開日 |
2023-08-03 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1371/journal.pone.0206748 |
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言語 |
ja |
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|
関連名称 |
10.1371/journal.pone.0206748 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Phenethyl isothiocyanate activates leptin signaling and decreases food intake |
|
言語 |
en |
| タイトル別表記 |
|
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その他のタイトル |
Phenethyl iosothiocyanate activates leptin signaling |
|
言語 |
en |
| 著者 |
ヤギ, ミホ
ナカツジ, ユキコ
マエダ, アユミ
オオタ, ヒロキ
カミクボ, リョウスケ
ミヨシ, ノリユキ
ナカムラ, ヨシマサ
赤川, 貢
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Obesity, a principal risk factor for the development of diabetes mellitus, heart disease, and hypertension, is a growing and serious health problem all over the world. Leptin is a weight-reducing hormone produced by adipose tissue, which decreases food intake via hypothalamic leptin receptors (Ob-Rb) and the Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway. Protein tyrosine phosphatase 1B (PTP1B) negatively regulates leptin signaling by dephosphorylating JAK2, and the increased activity of PTP1B is implicated in the pathogenesis of obesity. Hence, inhibition of PTP1B may help prevent and reduce obesity. In this study, we revealed that phenethyl isothiocyanate (PEITC), a naturally occurring isothiocyanate in certain cruciferous vegetables, potently inhibits recombinant PTP1B by binding to the reactive cysteinyl thiol. Moreover, we found that PEITC causes the ligand-independent phosphorylation of Ob-Rb, JAK2, and STAT3 by inhibiting cellular PTP1B in differentiated human SH-SY5Y neuronal cells. PEITC treatment also induced nuclear accumulation of phosphorylated STAT3, resulting in enhanced anorexigenic POMC expression and suppressed orexigenic NPY/AGRP expression. We demonstrated that oral administration of PEITC to mice significantly reduces food intake, and stimulates hypothalamic leptin signaling. Our results suggest that PEITC might help prevent and improve obesity. |
|
言語 |
en |
| 書誌情報 |
en : PLOS ONE
巻 13,
号 11,
p. e0206748,
発行日 2018-11-01
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
19326203 |
| 出版者 |
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|
出版者 |
PLOS |
|
言語 |
en |
| 権利情報 |
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|
言語 |
en |
|
権利情報 |
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| EID |
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|
識別子 |
387632 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
pone_13_11_e0206748.pdf (2.55 MB)
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