| Item type |
文献 / Documents(1) |
| 公開日 |
2023-09-01 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1038/srep21797 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1038/srep21797 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Visualizing Trimming Dependence of Biodistribution and Kinetics with Homo- and Heterogeneous N-Glycoclusters on Fluorescent Albumin |
|
言語 |
en |
| 著者 |
オグラ, アキヒロ
田原, 強
ノザキ, サトシ
モリモト, コウジ
キヅカ, ヤスヒコ
キタヅメ, シノブ
ハラ, ミツコ
コジマ, ソウイチ
オノエ, ヒロタカ
Kurbangalieva, Almira
タニグチ, ナオユキ
ワタナベ, ヤスヨシ
タナカ, カツノリ
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
A series of N-glycans, each sequentially trimmed from biantennary sialoglycans, were homo- or heterogeneously clustered efficiently on fluorescent albumin using a method that combined strain-promoted alkyne-azide cyclization and 6π-azaelectrocyclization. Noninvasive in vivo kinetics and dissection analysis revealed, for the first time, a glycan-dependent shift from urinary to gall bladder excretion mediated by sequential trimming of non-reducing end sialic acids. N-glycoalbumins that were trimmed further, in particular, GlcNAc- and hybrid biantennary-terminated congeners, were selectively taken up by sinusoidal endothelial and stellate cells in the liver, which are critical for diagnosis and treatment of liver fibrillation. Our glycocluster strategy can not only reveal the previously unexplored extracellular functions of N-glycan trimming, but will be classified as the newly emerging glycoprobes for diagnostic and therapeutic applications. |
|
言語 |
en |
| 書誌情報 |
en : Scientific Reports
巻 6,
p. 21797,
発行日 2016-02-23
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
20452322 |
| 出版者 |
|
|
出版者 |
Springer Nature |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| EID |
|
|
識別子 |
377916 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
srep_6_21797.pdf (4.36 MB)
.png)
