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circRNA : A New Biomarker and Therapeutic Target for Esophageal Cancer
https://tokushima-u.repo.nii.ac.jp/records/2010598
https://tokushima-u.repo.nii.ac.jp/records/20105981410bee8-22fc-48fd-bcd1-b233e3b12cb5
| 名前 / ファイル | ライセンス | アクション |
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biomed_10_7_1643.pdf (323 KB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||
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| 公開日 | 2023-01-26 | |||||||||||||||||||||||
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| アクセス権 | open access | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.3390/biomedicines10071643 | |||||||||||||||||||||||
| 関連名称 | 10.3390/biomedicines10071643 | |||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | circRNA : A New Biomarker and Therapeutic Target for Esophageal Cancer | |||||||||||||||||||||||
| 著者 |
ショウダ, カツトシ
× ショウダ, カツトシ
× 桑野, 由紀
WEKO
392
× イチカワ, ダイスケ
× 増田, 清士 |
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| 内容記述 | Circular RNAs (circRNAs) comprise a large class of endogenous non-coding RNA with covalently closed loops and have independent functions as linear transcripts transcribed from identical genes. circRNAs are generated by a “back-splicing” process regulated by regulatory elements in cis and associating proteins in trans. Many studies have shown that circRNAs play important roles in multiple processes, including splicing, transcription, chromatin modification, miRNA sponges, and protein decoys. circRNAs are highly stable because of their closed ring structure, which prevents them from degradation by exonucleases, and are more abundant in terminally differentiated cells, such as brains. Recently, it was demonstrated that numerous circRNAs are differentially expressed in cancer cells, and their dysfunction is involved in tumorigenesis and metastasis. However, the crucial functions of these circRNAs and the dysregulation of circRNAs in cancer are still unknown. In this review, we summarize the recent reports on the biogenesis and biology of circRNAs and then catalog the advances in using circRNAs as biomarkers and therapeutic targets for cancer therapy, particularly esophageal cancer. | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | circRNA | |||||||||||||||||||||||
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| 主題 | esophageal cancer | |||||||||||||||||||||||
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| 主題 | biomarker | |||||||||||||||||||||||
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| 主題 | therapeutic target | |||||||||||||||||||||||
| 書誌情報 |
en : Biomedicines 巻 10, 号 7, p. 1643, 発行日 2022-07-08 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 22279059 | |||||||||||||||||||||||
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| 出版者 | MDPI | |||||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||||
| 権利情報 | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | |||||||||||||||||||||||
| EID | ||||||||||||||||||||||||
| 識別子 | 388159 | |||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||
