| Item type |
文献 / Documents(1) |
| 公開日 |
2023-01-31 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3389/fimmu.2022.836923 |
|
|
言語 |
ja |
|
|
関連名称 |
10.3389/fimmu.2022.836923 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Markers of Memory CD8 T Cells Depicting the Effect of the BNT162b2 mRNA COVID-19 Vaccine in Japan |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
Markers of Memory CD8 |
|
言語 |
en |
| 著者 |
近藤, 博之
カゲヤマ, タカヒロ
タナカ, シゲル
大塚, 邦紘
九十九, 伸一
マシモ, ヨウイチ
オノウチ, ヨシヒロ
ナカジマ, ヒロシ
安友, 康二
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
BNT162b2, a nucleoside-modified mRNA vaccine for SARS-CoV-2 spike glycoprotein (S), provides approximately 95% efficacy for preventing COVID-19. However, it remains unclear how effectively memory CD8+ T cells are generated and which genetic and environmental factors affect the generation and function of memory CD8+ T cells elicited by this vaccine. Here, we investigated the frequency and functions of memory CD8+ T cells 3 weeks after the second vaccination in the Japanese population. Using a peptide-MHC pentamer, we detected an increased number of memory CD8+ T cells together with increased serum anti-S protein antibody in females compared with that in males, but the frequency of pentamer-positive cells was not positively correlated with antibody titers. Memory precursor effector cells (KLRG1-CD127+) among both CD8+ cells and pentamer+ cells and effector cells (CD38-HLA-DR+) among pentamer+ cells were more abundant in females than in males. Upon S protein-mediated stimulation of T cells, the intensity of CD107a and granzyme B expression was increased in females compared with that in males, indicating stronger memory CD8+ T cell responses in females than in males. Our studies showed that the BNT162b2 vaccine elicits increased memory CD8+ T cell proliferation and secondary CTL responses in females compared with those in males in the Japanese population. These findings provide an important basis for the distinct sex difference in cellular immune responses to mRNA vaccination and suggest that memory precursor effector cells can be one of markers to evaluate and boost cellular immunity induced by BNT162b2. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
COVID-19 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
T cell |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
CD8 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
vaccine |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
markers |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
antigen |
| 書誌情報 |
en : Frontiers in Immunology
巻 13,
p. 836923,
発行日 2022-04-28
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
16643224 |
| 出版者 |
|
|
出版者 |
Frontiers Media S.A. |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| EID |
|
|
識別子 |
385480 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
fimmu_13_836923.pdf (3.53 MB)
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