| Item type |
文献 / Documents(1) |
| 公開日 |
2023-02-10 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.3390/molecules27175459 |
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関連名称 |
10.3390/molecules27175459 |
| 出版タイプ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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タイトル |
Betuletol, a Propolis Component, Suppresses IL-33 Gene Expression and Effective against Eosinophilia |
| 著者 |
Shaha, Aurpita
Islam, Rezwanul
田中, 直伸
柏田, 良樹
福井, 裕行
武田, 憲昭
北村, 嘉章
水口, 博之
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| 抄録 |
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内容記述 |
Propolis, a resinous substance produced by honeybees, has been used in folk medicine since ancient times due to its many biological benefits such as antitumor, antioxidant, antimicrobial, anti-inflammatory, and immunomodulatory effects. Propolis contains flavonoids, terpenoids, aromatic aldehydes, and alcohols, which vary with different climate and environmental conditions. In our study, we examined the antiallergic activity of Brazilian green propolis (BGP) and isolated the active compound that can suppress an allergy-sensitive gene, IL-33, expression and eosinophilia. Ethanolic extract of BGP freeze-dried powder was fractionated with several solvent systems, and the active fractions were collected based on activity measurement. The single active compound was found by thin-layer chromatography. Using column chromatography and NMR, the active compound was isolated and identified as 3,5,7-trihydroxy-6,4’-dimethoxyflavone, also known as betuletol. Further, the antiallergic activity of that has been examined in PMA-induced up-regulation of IL-33 gene expression in Swiss 3T3 cells. Our data showed the IL-33 gene suppression both by BGP and the isolated active compound, betuletol. We also found that betuletol suppressed ERK phosphorylation, suggesting it could be effective in suppressing IL-33 mediated eosinophilic chronic inflammation and will provide new insights to develop potent therapeutics against allergic inflammations. |
| キーワード |
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主題 |
allergic rhinitis |
| キーワード |
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主題 |
betuletol |
| キーワード |
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|
主題 |
eosinophilia |
| キーワード |
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主題 |
IL-33 |
| キーワード |
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|
主題 |
propolis |
| 書誌情報 |
en : Molecules
巻 27,
号 17,
p. 5459,
発行日 2022-08-25
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
14203049 |
| 出版者 |
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|
出版者 |
MDPI |
| 権利情報 |
|
|
権利情報 |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| EID |
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識別子 |
391803 |
| 言語 |
|
|
言語 |
eng |
molecules_27_17_5459.pdf (1.94 MB)
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