| Item type |
文献 / Documents(1) |
| 公開日 |
2023-02-17 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1111/pcn.13373 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1111/pcn.13373 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Left DLPFC activity is associated with plasma kynurenine levels and can predict treatment response to escitalopram in major depressive disorder |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
DLPFC and KYN in MDD treatment response |
|
言語 |
en |
| 著者 |
カミシキリョウ, トシハル
オカダ, ゴウ
イタイ, エリ
マスダ, ヨシカズ
ヨコヤマ, サトシ
タカムラ, マサヒロ
フチカミ, マナブ
ヨシノ, アツオ
馬渡, 一諭
沼田, 周助
髙橋, 章
大森, 哲郎
オカモト, ヤスマサ
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Aim: To establish treatment response biomarkers that reflect the pathophysiology of depression, it is important to use an integrated set of features. This study aimed to determine the relationship between regional brain activity at rest and blood metabolites related to treatment response to escitalopram to identify the characteristics of depression that respond to treatment.
Methods: Blood metabolite levels and resting-state brain activity were measured in patients with moderate to severe depression (n = 65) before and after 6–8 weeks of treatment with escitalopram, and these were compared between Responders and Nonresponders to treatment. We then examined the relationship between blood metabolites and brain activity related to treatment responsiveness in patients and healthy controls (n = 36).
Results: Thirty-two patients (49.2%) showed a clinical response (>50% reduction in the Hamilton Rating Scale for Depression score) and were classified as Responders, and the remaining 33 patients were classified as Nonresponders. The pretreatment fractional amplitude of low-frequency fluctuation (fALFF) value of the left dorsolateral prefrontal cortex (DLPFC) and plasma kynurenine levels were lower in Responders, and the rate of increase of both after treatment was correlated with an improvement in symptoms. Moreover, the fALFF value of the left DLPFC was significantly correlated with plasma kynurenine levels in pretreatment patients with depression and healthy controls.
Conclusion: Decreased resting-state regional activity of the left DLPFC and decreased plasma kynurenine levels may predict treatment response to escitalopram, suggesting that it may be involved in the pathophysiology of major depressive disorder in response to escitalopram treatment. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
dorsolateral prefrontal cortex |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
fMRI |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
kynurenine |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
major depressive disorder |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
metabolomics |
| 書誌情報 |
en : Psychiatry and Clinical Neurosciences
巻 76,
号 8,
p. 367-376,
発行日 2022-05-11
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
14401819 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11040669 |
| 出版者 |
|
|
出版者 |
Wiley |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Japanese Society of Psychiatry and Neurology |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
| EID |
|
|
識別子 |
390854 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
pcn_76_8_367.pdf (804 KB)
.png)
