| Item type |
文献 / Documents(1) |
| 公開日 |
2023-02-17 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
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|
関連識別子 |
https://doi.org/10.1126/sciadv.abq0008 |
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関連名称 |
10.1126/sciadv.abq0008 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
AFF3, a susceptibility factor for autoimmune diseases, is a molecular facilitator of immunoglobulin class switch recombination |
| 著者 |
九十九, 伸一
Subramani, Poorani Ganesh
Seija, Noé
タバタ, ミズホ
前川, 洋一
モリ, ユウヤ
石舟, 智恵子
イトウ, ヤスシ
オオタ, ミネト
フジオ, ケイシ
Di Noia, Javier M.
安友, 康二
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| 抄録 |
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内容記述 |
Immunoglobulin class switch recombination (CSR) plays critical roles in controlling infections and inflammatory tissue injuries. Here, we show that AFF3, a candidate gene for both rheumatoid arthritis and type 1 diabetes, is a molecular facilitator of CSR with an isotype preference. Aff3-deficient mice exhibit low serum levels of immunoglobulins, predominantly immunoglobulin G2c (IgG2c) followed by IgG1 and IgG3 but not IgM. Furthermore, Aff3-deficient mice show weak resistance to Plasmodium yoelii infection, confirming that Aff3 modulates immunity to this pathogen. Mechanistically, the AFF3 protein binds to the IgM and IgG1 switch regions via a C-terminal domain, and Aff3 deficiency reduces the binding of AID to the switch regions less efficiently. One AFF3 risk allele for rheumatoid arthritis is associated with high mRNA expression of AFF3, IGHG2, and IGHA2 in human B cells. These findings demonstrate that AFF3 directly regulates CSR by facilitating the recruitment of AID to the switch regions. |
| 書誌情報 |
en : Science Advances
巻 8,
号 34,
p. eabq0008,
発行日 2022-08-24
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
23752548 |
| 出版者 |
|
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出版者 |
American Association for the Advancement of Science |
| 権利情報 |
|
|
権利情報 |
© 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). |
| EID |
|
|
識別子 |
392146 |
| 言語 |
|
|
言語 |
eng |
sciadv_8_34_eabq0008.pdf (1.87 MB)
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