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The Effect of Iontophoretic-Delivered Polyplex Vaccine on Melanoma Regression
https://tokushima-u.repo.nii.ac.jp/records/2010698
https://tokushima-u.repo.nii.ac.jp/records/2010698c8993aba-e4ed-4269-a8f2-1a8de008bf25
| 名前 / ファイル | ライセンス | アクション |
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bpb_46_3_494.pdf (1.88 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||
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| 公開日 | 2023-03-09 | |||||||||||||||||||||||
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| アクセス権 | open access | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1248/bpb.b22-00873 | |||||||||||||||||||||||
| 関連名称 | 10.1248/bpb.b22-00873 | |||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | The Effect of Iontophoretic-Delivered Polyplex Vaccine on Melanoma Regression | |||||||||||||||||||||||
| 著者 |
Husseini, Rabab A.
× Husseini, Rabab A.
× 福田, 達也× 大園, 瑞音
WEKO
1435
× Hasan, Azza A.
× El Megrab, Nagia A.
× 小暮, 健太朗
WEKO
1139
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| 内容記述 | Although the strategy in cancer vaccination is to provide a therapeutic effect against an established tumor, there is an urgent need to develop prophylactic vaccines for non-viral cancers. In this study, we prepared polyplex nanoparticles through electrostatic interactions between a positively-charged modified tumor associated antigen, namely human derived melanoma gp10025–33 peptide (KVPRNQDWL-RRRR), and a negatively charged cytosine-phosphate-guanosine motif (CpG-ODN) adjuvant. We previously demonstrated successful transdermal delivery of various hydrophilic macromolecules by iontophoresis (IP) using weak electricity. Herein, we investigated the effectiveness of IP in the transdermal delivery of a prophylactic polyplex vaccine. IP was successful in establishing a homogenous distribution of the vaccine throughout skin. Efficacy of the vaccine was demonstrated against melanoma growth. A significant tumor regression effect was observed, which was confirmed by elevated mRNA expression levels of various cytokines, mainly interferon (IFN)-γ, as well as infiltration of cytotoxic CD8+ T cells. Additionally, we evaluated the therapeutic effect of the vaccine and we found a significant reduction in tumor burden. Stimulation of systemic immunity was confirmed by upregulation of IFN-γ. This is the first report to demonstrate the use of IP in the transdermal delivery of a prophylactic melanoma vaccine. | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | prophylactic cancer vaccine | |||||||||||||||||||||||
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| 主題 | iontophoresis | |||||||||||||||||||||||
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| 主題 | polyplex nanoparticle | |||||||||||||||||||||||
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| 主題 | antigen peptide | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | cytosine-phosphate- guanosine motif (CpG-ODN) adjuvant | |||||||||||||||||||||||
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| 主題 | melanoma | |||||||||||||||||||||||
| 書誌情報 |
en : Biological and Pharmaceutical Bulletin 巻 46, 号 3, p. 494-504, 発行日 2023-03-01 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 13475215 | |||||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||||
| 収録物識別子 | AA11696048 | |||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||
| 出版者 | The Pharmaceutical Society of Japan | |||||||||||||||||||||||
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| 識別子 | 393581 | |||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||
