| Item type |
文献 / Documents(1) |
| 公開日 |
2023-01-13 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1007/s11604-022-01364-0 |
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|
言語 |
ja |
|
|
関連名称 |
10.1007/s11604-022-01364-0 |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
|
|
タイトル |
New quantitative indices of cardiac amyloidosis with 99mTc-pyrophosphate scintigraphy |
|
言語 |
en |
| 著者 |
マツダ, ノリタケ
大塚, 秀樹
大谷, 環樹
アザネ, ショウタ
クニカネ, ヤマト
音見, 暢一
ウエキ, ユウヤ
クボタ, マサヒロ
アマノ, マサフミ
八木, 秀介
佐田, 政隆
原田, 雅史
|
| 抄録 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
Purpose: Amyloid light chain (AL) and transthyretin (ATTR) are the major subtypes of cardiac amyloidosis (CA). 99mTc-pyrophosphate (PYP) scintigraphy is used to differentiate ATTR from other CA subtypes. We adapted the standardized uptake value (SUV) for 99mTc-PYP and proposed two quantitative indices, amyloid deposition volume (AmyDV) and total amyloid uptake (TAU). This study aimed to evaluate the utility of these quantitative indices in differentiating ATTR from non-ATTRs.
Materials and methods: Before the SUV measurement, the Becquerel calibration factor (BCF) of 99mTc was obtained by a phantom experiment. Thirty-two patients who had undergone hybrid SPECT/CT imaging 3 h after injection of 99mTc-PYP (370 MBq) were studied. CT attenuation correction for image reconstruction was applied in all. We calculated SUV, AmyDV, and TAU using a quantitative analysis software program for bone SPECT (GI-BONE) and analyzed AmyDV using two methods: Threshold method (set 40%); and constant value method (average SUVmax of ribs). We assessed the diagnostic ability of heart-to-contralateral lung (H/CL) ratio, SUV, AmyDV, and TAU to differentiate ATTR from non-ATTR using receiver operating characteristic (ROC) analysis.
Results: Statistically significant differences in all quantitative indices were observed between ATTR and non-ATTR. The area under the curve of each quantitative index for discriminating between ATTR and non-ATTR were as follows: H/CL, 0.997; SUVmax, 0.953; SUVmean (M1), 0.964; SUVmean (M2), 0.969; AmyDV (M1), 0.875; AmyDV (M2), 0.974; and TAU, 0.974. The AmyDV (M2) had higher diagnostic ability than AmyDV (M1). Thus, TAU was calculated as AmyDV (M2) × SUVmean (M2). In the ROC curve, SUV, AmyDV, and TAU had almost the same diagnostic ability as H/CL in distinguishing ATTR from non-ATTRs.
Conclusions: We propose two novel 3D-based quantitative parameters (AmyDV and TAU) that have almost equal ability to discriminate ATTR from non-ATTR. |
|
言語 |
en |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Cardiac amyloidosis (CA) |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Standardized uptake value (SUV) |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Amyloid deposition volume (AmyDV) |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Total amyloid uptake (TAU) |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Becquerel calibration factor (BCF) |
| 書誌情報 |
en : Japanese Journal of Radiology
巻 41,
号 4,
p. 428-436,
発行日 2022-11-30
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1867108X |
| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
18671071 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12375935 |
| 出版者 |
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|
出版者 |
Japan Radiological Society |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Springer Nature |
|
言語 |
en |
| 備考 |
|
|
言語 |
ja |
|
値 |
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use (https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms), but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s11604-022-01364-0 |
| EID |
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|
識別子 |
393335 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
jjr_41_4_428.pdf (1.16 MB)
