WEKO3
アイテム
Comparison of hemodynamics during induction of general anesthesia with remimazolam and target-controlled propofol in middle-aged and elderly patients : a single-center, randomized, controlled trial
https://tokushima-u.repo.nii.ac.jp/records/2010706
https://tokushima-u.repo.nii.ac.jp/records/20107065133ad7b-2e4a-4654-8bb5-ccee2f02a1de
| 名前 / ファイル | ライセンス | アクション |
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bmca_23_14.pdf (1.14 MB)
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| 公開日 | 2023-01-19 | |||||||||||||||||||||||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1186/s12871-023-01974-9 | |||||||||||||||||||||||||||||||||||||||||
| 関連名称 | 10.1186/s12871-023-01974-9 | |||||||||||||||||||||||||||||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||||||||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||||||||||||||||||||
| タイトル | Comparison of hemodynamics during induction of general anesthesia with remimazolam and target-controlled propofol in middle-aged and elderly patients : a single-center, randomized, controlled trial | |||||||||||||||||||||||||||||||||||||||||
| 著者 |
セキグチ, リョウ
× セキグチ, リョウ
× 木下, 倫子
WEKO
453
× 川西, 良典
WEKO
592
× 角田, 奈美
WEKO
454
× 酒井, 陽子
WEKO
656
× 田中, 克哉
WEKO
1645
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| 内容記述 | Background Remimazolam confers a lower risk of hypotension than propofol. However, no studies have compared the efficacy of remimazolam and propofol administered using target-controlled infusion (TCI). This study aimed to investigate hemodynamic effects of remimazolam and target-controlled propofol in middle-aged and elderly patients during the induction of anesthesia. Methods Forty adults aged 45–80 years with the American Society of Anesthesiologists Physical Status 1–2 were randomly assigned to remimazolam or propofol group (n = 20 each). Patients received either remimazolam (12 mg/kg/h) or propofol (3 μg/mL, TCI), along with remifentanil for inducing anesthesia. We recorded the blood pressure, heart rate (HR), and estimated continuous cardiac output (esCCO) using the pulse wave transit time. The primary outcome was the maximum change in mean arterial pressure (MAP) after induction. Secondary outcomes included changes in HR, cardiac output (CO), and stroke volume (SV). Results MAP decreased after induction of anesthesia in both groups, without significant differences between the groups (− 41.1 [16.4] mmHg and − 42.8 [10.8] mmHg in remimazolam and propofol groups, respectively; mean difference: 1.7 [95% confidence interval: − 8.2 to 4.9]; p = 0.613). Furthermore, HR, CO, and SV decreased after induction in both groups, without significant differences between the groups. Remimazolam group had significantly shorter time until loss of consciousness than propofol group (1.7 [0.7] min and 3.5 [1.7] min, respectively; p < 0.001). However, MAP, HR, CO, and SV were not significantly different between the groups despite adjusting time until loss of consciousness as a covariate. Seven (35%) and 11 (55%) patients in the remimazolam and propofol groups, respectively, experienced hypotension (MAP < 65 mmHg over 2.5 min), without significant differences between the groups (p = 0.341). Conclusions Hemodynamics were not significantly different between remimazolam and target-controlled propofol groups during induction of anesthesia. Thus, not only the choice but also the dose and usage of anesthetics are important for hemodynamic stability while inducing anesthesia. Clinicians should monitor hypotension while inducing anesthesia with remimazolam as well as propofol. |
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| キーワード | ||||||||||||||||||||||||||||||||||||||||||
| 主題 | Hemodynamics | |||||||||||||||||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||||||||||||||||
| 主題 | Hypotension | |||||||||||||||||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||||||||||||||||
| 主題 | Remimazolam | |||||||||||||||||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||||||||||||||||
| 主題 | Propofol | |||||||||||||||||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||||||||||||||||
| 主題 | Target-controlled infusion | |||||||||||||||||||||||||||||||||||||||||
| 書誌情報 |
en : BMC Anesthesiology 巻 23, p. 14, 発行日 2023-01-10 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||||||||||||||||||||
| 収録物識別子 | 14712253 | |||||||||||||||||||||||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||||||||||||||||||||||
| 収録物識別子 | AA12034694 | |||||||||||||||||||||||||||||||||||||||||
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| 出版者 | BioMed Central | |||||||||||||||||||||||||||||||||||||||||
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| 出版者 | Springer Nature | |||||||||||||||||||||||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||||||||||||||||||||||
| 権利情報 | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. | |||||||||||||||||||||||||||||||||||||||||
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| 識別子 | 393664 | |||||||||||||||||||||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||||||||||||||||||||
