| Item type |
文献 / Documents(1) |
| 公開日 |
2023-03-09 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.3390/ph16030397 |
|
|
関連名称 |
10.3390/ph16030397 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Increasing Skeletal Muscle Mass in Mice by Non-Invasive Intramuscular Delivery of Myostatin Inhibitory Peptide by Iontophoresis |
| 著者 |
ミチウエ, コウキ
タカヤマ, ケンタロウ
タニグチ, アツヒコ
ハヤシ, ヨシオ
小暮, 健太朗
|
| 抄録 |
|
|
内容記述 |
Sarcopenia is a major public health issue that affects older adults. Myostatin inhibitory-D-peptide-35 (MID-35) can increase skeletal muscle and is a candidate therapeutic agent, but a non-invasive and accessible technology for the intramuscular delivery of MID-35 is required. Recently, we succeeded in the intradermal delivery of various macromolecules, such as siRNA and antibodies, by iontophoresis (ItP), a non-invasive transdermal drug delivery technology that uses weak electricity. Thus, we expected that ItP could deliver MID-35 non-invasively from the skin surface to skeletal muscle. In the present study, ItP was performed with a fluorescently labeled peptide on mouse hind leg skin. Fluorescent signal was observed in both skin and skeletal muscle. This result suggested that the peptide was effectively delivered to skeletal muscle from skin surface by ItP. Then, the effect of MID-35/ItP on skeletal muscle mass was evaluated. The skeletal muscle mass increased 1.25 times with ItP of MID-35. In addition, the percentage of new and mature muscle fibers tended to increase, and ItP delivery of MID-35 showed a tendency to induce alterations in the levels of mRNA of genes downstream of myostatin. In conclusion, ItP of myostatin inhibitory peptide is a potentially useful strategy for treating sarcopenia. |
| キーワード |
|
|
主題 |
sarcopenia |
| キーワード |
|
|
主題 |
myostatin inhibitory peptides |
| キーワード |
|
|
主題 |
iontophoresis |
| キーワード |
|
|
主題 |
intramuscular deliver |
| キーワード |
|
|
主題 |
peptide delivery |
| キーワード |
|
|
主題 |
weak electricity |
| キーワード |
|
|
主題 |
transdermal |
| 書誌情報 |
en : Pharmaceuticals
巻 16,
号 3,
p. 397,
発行日 2023-03-06
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
14248247 |
| 出版者 |
|
|
出版者 |
MDPI |
| 権利情報 |
|
|
権利情報 |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| EID |
|
|
識別子 |
394326 |
| 言語 |
|
|
言語 |
eng |
ph_16_3_397.pdf (3.19 MB)
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