| Item type |
文献 / Documents(1) |
| 公開日 |
2023-03-29 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3390/molecules27227670 |
|
|
言語 |
ja |
|
|
関連名称 |
10.3390/molecules27227670 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Neurite Outgrowth-Promoting Compounds from the Petals of Paeonia lactiflora in PC12 Cells |
|
言語 |
en |
| 著者 |
古賀, 武尊
イトウ, ヒデユキ
イワオカ, ユウジ
ノシタ, トシロウ
田井, 章博
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Isorhamnetin-3-O-glucoside and astragalin, flavonol glucosides, were isolated from the petals of Paeonia lactiflora as neurite outgrowth-promoting compounds. Isoquercitrin, formed by demethylating the B ring of isorhamnetin-3-O-glucoside or by adding a hydroxyl group to the B ring of astragalin, was evaluated for neurite outgrowth-promoting activity and was compared with the activities of isorhamnetin-3-O-glucoside and astragalin. The activities of isorhamnetin, kaempferol, and quercetin, aglycones corresponding to isorhamnetin-3-O-glucoside, astragalin, and isoquercitrin, respectively, were also evaluated. Isorhamnetin-3-O-glucoside and astragalin showed much stronger neurite outgrowth-promoting activities than the activities of the other tested flavonoids. They exhibited relatively weak anti-oxidant activities and moderate AChE inhibitory activities compared to the activities of the other tested flavonoids. Isorhamnetin-3-O-glucoside and astragalin promoted morphological neurite outgrowth and the expression of neurofilaments induced by NGF in PC12 cells. Isorhamnetin-3-O-glucoside and astragalin might be candidate compounds as neural differentiation agents in peripheral nerves and functional food ingredients preventing cognitive decline. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Paeonia lactiflora |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
PC12 cells |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
NGF |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
isorhamnetin-3-O-glucoside |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
astragalin |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
neurite outgrowth-promoting activity |
| 書誌情報 |
en : Molecules
巻 27,
号 22,
p. 7670,
発行日 2022-11-08
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
14203049 |
| 出版者 |
|
|
出版者 |
MDPI |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| EID |
|
|
識別子 |
392841 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
molecules_27_22_7670.pdf (1.73 MB)
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