| Item type |
文献 / Documents(1) |
| 公開日 |
2023-03-29 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.3892/OL.2022.13356 |
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関連名称 |
10.3892/OL.2022.13356 |
| 出版タイプ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
Polymethoxylated flavone sudachitin is a safe anticancer adjuvant that targets glycolysis in cancer‑associated fibroblasts |
| タイトル別表記 |
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その他のタイトル |
SUDACHITIN IS A SAFE ANTICANCER ADJUVANT TARGETING THE TME |
| 著者 |
Chen, Shuhai
西, 正暁
森根, 裕二
吉川, 幸造
徳永, 卓哉
柏原, 秀也
髙須, 千絵
和田, 佑馬
良元, 俊昭
中本, 晶子
酒井, 徹
島田, 光生
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| 抄録 |
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内容記述 |
Sudachitin is a polymethoxylated flavone found in the peel of Citrus sudachi, a unique specialty citrus fruit in Tokushima Prefecture, Japan. Previous reports have demonstrated that sudachitin has anti‑inflammatory and metabolic regulatory activities. However, to the best of our knowledge, no studies have explored whether sudachitin can act as an antitumor therapeutic agent by regulating metabolic functions in the tumor microenvironment. In the present study, cell proliferation and cytotoxicity assays were used to determine whether sudachitin inhibited the in vitro growth of liver cancer and pancreatic carcinoma, cholangiocarcinoma and colorectal cancer cells and to compare its toxicity against normal fibroblasts and induced cancer‑associated fibroblasts (CAFs). Using lactate assays and reverse transcription‑quantitative PCR, the effects of sudachitin on glycolysis in CAFs were investigated. The effects of CAFs on malignant tumor cells were evaluated in vitro using cell proliferation, wound healing and invasion assays. As result, sudachitin inhibited various types of tumor cells with different half‑maximal inhibitory concentrations. Treatment with 50 µM sudachitin for 48 h suppressed tumor and CAFs proliferation but was not cytotoxic against normal fibroblasts. This dose also inhibited glycolysis in CAFs and, thus, diminished their pro‑tumorigenic activities. Overall, the present study revealed that sudachitin has promise as a safe and widely available natural antitumor adjuvant. |
| キーワード |
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|
主題 |
cancer‑associated fibroblasts |
| キーワード |
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|
主題 |
sudachitin |
| キーワード |
|
|
主題 |
glycolysis |
| キーワード |
|
|
主題 |
reverse Warburg effect |
| キーワード |
|
|
主題 |
antitumor |
| 書誌情報 |
en : Oncology Letters
巻 24,
号 1,
p. 236,
発行日 2022-05-31
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
17921074 |
| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
17921082 |
| 出版者 |
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出版者 |
Spandidos Publications |
| 権利情報 |
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|
権利情報 |
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License. |
| EID |
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|
識別子 |
393992 |
| 言語 |
|
|
言語 |
eng |
ol_24_1_236.pdf (2.59 MB)
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