| Item type |
文献 / Documents(1) |
| 公開日 |
2023-03-29 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3892/or.2022.8315 |
|
|
言語 |
ja |
|
|
関連名称 |
10.3892/or.2022.8315 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Blue light irradiation inhibits the growth of colon cancer and activation of cancer‑associated fibroblasts |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
BLUE LED FOR COLON CANCER AND CAFs |
|
言語 |
en |
| 著者 |
良元, 俊昭
島田, 光生
徳永, 卓哉
中尾, 寿宏
西, 正暁
髙須, 千絵
柏原, 秀也
和田, 佑馬
オキカワ, ショウヘイ
吉川, 幸造
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Irradiation with a specific wavelength of light using light‑emitting diodes (LEDs) has various effects on cells and organisms. Recently, the antitumor effects of visible blue light on tumor cells were reported; however, the mechanism and effects on the tumor microenvironment remain unclear. Human colon cancer cells (HCT‑116) were injected into the rectal wall of nude mice. Tumors were irradiated with a 465‑nm LED light at 30 mW/cm2 for 30 min. Tumor volumes and the expression levels of opsin 3 (Opn3), autophagy‑related factors, cancer‑associated fibroblast (CAF) markers, and programmed cell death 1‑ligand (PD‑L1) were measured. Additionally, human intestinal fibroblasts were cultured in HCT116‑conditioned medium (CM) to prepare CAFs. CAFs were divided into an LED group and a control group, and the effect of the LED light on CAF activation in colon cancer cells was examined. Irradiation with blue LED light suppressed tumor growth; Opn3 expression was localized to the cell membrane in the LED group. Irradiated tumors exhibited increased autophagy‑related gene expression. Furthermore, in the LED group, TGF‑β and α‑SMA expression levels in the fibroblasts were decreased. Regarding CAFs, α‑SMA and IL‑6 expression levels were decreased in the LED group. HCT‑116 cells cultured in CAF‑CM with LED irradiation showed no enhanced migration or invasion. In the HCT‑116 cells cultured in CM of CAFs irradiated with LED, the relative increase in PD‑L1 expression was lower than that noted in the CAF‑CM without LED irradiation. Blue LED light may have a direct antitumor effect on colon cancer and also an inhibitory effect on CAFs. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
blue light‑emitting diode |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
colorectal cancer |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
cancer‑associated fibroblasts |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
opsin 3 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
in vivo |
| 書誌情報 |
en : Oncology Reports
巻 47,
号 5,
p. 104,
発行日 2022-04-12
|
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1021335X |
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
17912431 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11016405 |
| 出版者 |
|
|
出版者 |
Spandidos Publications |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License. |
| EID |
|
|
識別子 |
393990 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
or_47_5_104.pdf (6 MB)
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