| Item type |
文献 / Documents(1) |
| 公開日 |
2023-04-25 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1111/cts.13419 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1111/cts.13419 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Evaluation of the potential complication of interstitial lung disease associated with antifibrotic drugs using data from databases reporting spontaneous adverse effects |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
ILD CAUSED BY ANTIFIBROTIC AGENTS |
|
言語 |
en |
| 著者 |
ナワ, ヒデキ
濱野, 裕章
新村, 貴博
ミヤタ, コウジ
八木, 健太
合田, 光寛
座間味, 義人
石澤, 啓介
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Interstitial lung disease (ILD), as an adverse effect of certain drugs, leads to inflammation and damage in the walls of the alveoli, making it difficult for the alveoli to take up oxygen. Interstitial pneumonia with no identifiable cause is called idiopathic interstitial pneumonia (IIP), and, among the major IIPs, idiopathic pulmonary fibrosis (IPF) is diagnosed in about half of patients. Current treatment options are limited, among which the antifibrotic drugs nintedanib (Ofev) and pirfenidone (Pirespa) are the first-line drugs. In this study, we investigated the incidence of ILD possibly caused by antifibrotic agents using data from the Japanese Adverse Drug Event Report (JADER) database, a database of spontaneous adverse event reports published by the Pharmaceuticals and Medical Devices Agency (PMDA), and the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS), published by the FDA. We used the FAERS and JADER to detect the signals of adverse events on the basis of reporting odds ratios. The relationship between indications and adverse events was clarified by separating indications and adverse events using the spontaneous adverse event reporting database with novel drug involvement. Regarding the involvement of nintedanib and pirfenidone in the development of ILD, JADER and FAERS showed signals for both nintedanib and pirfenidone as suspect drugs, and no signals for nintedanib or pirfenidone as concomitant drug interactions were detected. We highlight this because there are only a few effective drugs for IPF, and effective and safe drug therapies should be implemented by taking into consideration drug-induced ILD. |
|
言語 |
en |
| 書誌情報 |
en : Clinical and Translational Science
巻 15,
号 12,
p. 2982-2988,
発行日 2022-09-20
|
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
17528062 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12625737 |
| 出版者 |
|
|
出版者 |
Wiley |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
American Society for Clinical Pharmacology and Therapeutics |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
| EID |
|
|
識別子 |
394583 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
cts_15_12_2982.pdf (134 KB)
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