| Item type |
文献 / Documents(1) |
| 公開日 |
2023-06-02 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
|
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|
関連識別子 |
https://doi.org/10.1038/s42004-023-00838-0 |
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関連名称 |
10.1038/s42004-023-00838-0 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
1,3a,6a-Triazapentalene derivatives as photo-induced cytotoxic small fluorescent dyes |
| 著者 |
辻, 大輔
中山, 淳
ヤマモト, リコ
ナガノ, シュウジ
タニグチ, タカシ
佐藤, 亮太
カランジット, サンギータ
六車, 直樹
高山, 哲治
伊藤, 孝司
難波, 康祐
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| 抄録 |
|
|
内容記述 |
1,3a,6a-Triazapentalene (TAP) is a compact fluorescent chromophore whose fluorescence properties vary greatly depending on the substituents on the TAP ring. This study investigated the photo-induced cytotoxicities of various TAP derivatives. Among the derivatives, 2-p-nitrophenyl-TAP showed significant cytotoxicity to HeLa cells under UV irradiation but no cytotoxicity without UV. In addition, the photo-induced cytotoxicity of 2-p-nitirophenyl-TAP was found to be cancer cell selective and effective against HeLa cells and HCT 116 cells. Under UV irradiation, 2-p-nitrophenyl-TAP generated reactive oxygen species (ROS) that induced an apoptosis and ferroptosis in cancer cells. Therefore, it was revealed that 2-p-nitrophenyl-TAP is the most compact dye that can generate ROS by photoirradiation. |
| 書誌情報 |
en : Communications Chemistry
巻 6,
p. 37,
発行日 2023-02-22
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
23993669 |
| 出版者 |
|
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出版者 |
Springer Nature |
| 権利情報 |
|
|
権利情報 |
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| EID |
|
|
識別子 |
396501 |
| 言語 |
|
|
言語 |
eng |
commschem_6_37.pdf (4.79 MB)
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