| Item type |
文献 / Documents(1) |
| 公開日 |
2023-06-20 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_db06 |
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資源タイプ |
doctoral thesis |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1002/ddr.22013 |
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関連名称 |
10.1002/ddr.22013 |
| 出版タイプ |
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出版タイプ |
NA |
|
出版タイプResource |
http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
| タイトル |
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|
タイトル |
Differential effects of proton pump inhibitors and vonoprazan on vascular endothelial growth factor expression in cancer cells |
| タイトル別表記 |
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その他のタイトル |
がん細胞におけるvascular endothelial growth factor発現に対するプロトンポンプ阻害剤とボノプラザンの効果の違い |
| タイトル別表記 |
|
|
その他のタイトル |
Effects of PPIs and vonoprazan on VEGF expression in cancer cells |
| 著者 |
安藤, 里英
八木, 健太
タカオカ, マユ
サカジリ, ユウコ
シバタ, トモカズ
サワダ, リュウスケ
マルオ, アキノリ
ミヤタ, コウジ
相澤, 風花
濱野, 裕章
新村, 貴博
(井澤)石澤, 有紀
合田, 光寛
坂口, 暁
座間味, 義人
ヤマニシ, ヨシヒロ
石澤, 啓介
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| 抄録 |
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内容記述 |
Background. Proton pump inhibitors (PPIs) are potent inhibitors of gastric acid secretion, used as first-line agents in treating peptic ulcers. However, we have previously reported that PPIs may diminish the therapeutic effect of anti-vascular endothelial growth factor (VEGF) drugs in patients with cancer. In this study, we explored the effects of vonoprazan, a novel gastric acid secretion inhibitor used for the treatment of peptic ulcers, on the secretion of VEGF in cancer cells and attempted to propose it as an alternative PPI for cancer chemotherapy. Methods. The effects of PPI and vonoprazan on VEGF expression in cancer cells were compared by real-time rt-PCR and ELISA. The interaction of vonoprazan and PPIs with transcriptional regulators by docking simulation analysis. Results. In various cancer cell lines, including the human colorectal cancer cell line (LS174T), PPI increased VEGF mRNA expression and VEGF protein secretion, while this effect was not observed with vonoprazan. Molecular docking simulation analysis showed that vonoprazan had a lower binding affinity for estrogen receptor alpha (ER-α), one of the transcriptional regulators of VEGF, compared to PPI. Although the PPI-induced increase in VEGF expression was counteracted by pharmacological ER-α inhibition, the effect of vonoprazan on VEGF expression was unchanged. Conclusions. Vonoprazan does not affect VEGF expression in cancer cells, which suggests that vonoprazan might be an alternative to PPIs, with no interference with the therapeutic effects of anti-VEGF cancer chemotherapy. |
| キーワード |
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|
主題 |
Proton pump inhibitors |
| キーワード |
|
|
主題 |
vonoprazan |
| キーワード |
|
|
主題 |
lansoprazole |
| キーワード |
|
|
主題 |
fulvestrant |
| キーワード |
|
|
主題 |
vascular endothelial growth factor |
| 書誌情報 |
en : Drug Development Research
巻 84,
号 1,
p. 75-83,
発行日 2022-12-09
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
10982299 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10654891 |
| 出版者 |
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|
出版者 |
Wiley |
| 備考 |
|
|
値 |
内容要旨・審査要旨・論文本文の公開
本論文は，著者Rie Ando-Matsuokaの学位論文として提出され，学位審査・授与の対象となっている。
学位授与者所属 : 徳島大学大学院医学研究科（医学専攻） |
| 権利情報 |
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|
権利情報 |
This is the peer reviewed version of the following article: Ando-Matsuoka, R., Yagi, K., Takaoka, M., Sakajiri, Y., Shibata, T., Sawada, R., Maruo, A., Miyata, K., Aizawa, F., Hamano, H., Niimura, T., Izawa-Ishizawa, Y., Goda, M., Sakaguchi, S., Zamami, Y., Yamanishi, Y., & Ishizawa, K. (2023). Differential effects of proton pump inhibitors and vonoprazan on vascular endothelial growth factor expression in cancer cells. Drug Development Research, 84, 75– 83., which has been published in final form at https://doi.org/10.1002/ddr.22013. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. |
| EID |
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識別子 |
394580 |
| 言語 |
|
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言語 |
eng |
| 報告番号 |
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学位授与番号 |
甲第3699号 |
| 学位記番号 |
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|
値 |
甲医第1569号 |
| 学位授与年月日 |
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|
学位授与年月日 |
2023-03-23 |
| 学位名 |
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学位名 |
博士（医学） |
| 学位授与機関 |
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学位授与機関名 |
徳島大学 |
k3699_abstract.pdf (122 KB)
