| Item type |
文献 / Documents(1) |
| 公開日 |
2023-06-20 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_db06 |
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資源タイプ |
doctoral thesis |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1016/j.bbrc.2020.05.165 |
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関連名称 |
10.1016/j.bbrc.2020.05.165 |
| 出版タイプ |
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出版タイプ |
NA |
|
出版タイプResource |
http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
| タイトル |
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|
タイトル |
Assessment of insulin resistance in the skeletal muscle of mice using positron emission tomography/computed tomography imaging |
| タイトル別表記 |
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その他のタイトル |
PET/CTを用いたマウス骨格筋インスリン抵抗性の評価 |
| 著者 |
ミヤタケ, ユミコ
三島, 優奈
堤, 理恵
大谷, 環樹
スエマサ, ナオヤ
升本, 早枝子
黒田, 雅士
阪上, 浩
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| 抄録 |
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内容記述 |
Measuring glucose uptake in the skeletal muscle in vivo is an effective method to determine glucose metabolism abnormalities as the skeletal muscle is the principal tissue responsible for glucose disposal and is a major site of peripheral insulin resistance. In this study, we investigated the pathological glucose metabolism dynamics of the skeletal muscle of C57BL/6J mice in a noninvasive and time-sequential manner using positron emission tomography/computed tomography (PET/CT), an imaging technique that uses radioactive substances to visualize and measure metabolic processes in the body, with [18F]-fluoro-2-deoxy-D-glucose (FDG). FDG-PET/CT imaging revealed that insulin administration and exercise load significantly increased FDG accumulation in the skeletal muscle of C57BL/6J mice. FDG accumulation was lower in the skeletal muscle of 14-week-old db/db diabetic model mice exhibiting remarkable insulin resistance compared to that of 7-week-old db/db mice. Based on the continuous observation of FDG accumulation over time in diet-induced obese (DIO) mice, FDG accumulation significantly decreased in 17-week-old mice after the acquisition of insulin resistance. Although insulin-induced glucose uptake in the skeletal muscle was markedly attenuated in 20-week-old DIO mice that had already developed insulin resistance, exercise load effectively increased FDG uptake in the skeletal muscle. Thus, we successfully confirmed that glucose uptake accompanied by insulin administration and exercise load increased in the skeletal muscle using PET-CT. FDG-PET/CT might be an effective tool that could noninvasively capture the chronological changes of metabolic abnormalities in the skeletal muscle of mice. |
| キーワード |
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|
主題 |
PET/CT |
| キーワード |
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|
主題 |
Insulin resistance |
| キーワード |
|
|
主題 |
Skeletal muscle |
| キーワード |
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|
主題 |
Glucose metabolism |
| キーワード |
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主題 |
Diabetes |
| キーワード |
|
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主題 |
FDG |
| 書誌情報 |
en : Biochemical and Biophysical Research Communications
巻 528,
号 3,
p. 499-505,
発行日 2020-06-05
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0006291X |
| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
10902104 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00564395 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11542044 |
| 出版者 |
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|
出版者 |
Elsevier |
| 備考 |
|
|
値 |
内容要旨・審査要旨・論文本文の公開
本論文は，著者Yuna Mishimaの学位論文として提出され，学位審査・授与の対象となっている。 |
| EID |
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識別子 |
367805 |
| 言語 |
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言語 |
eng |
| 報告番号 |
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|
学位授与番号 |
甲第3706号 |
| 学位記番号 |
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|
値 |
甲栄第294号 |
| 学位授与年月日 |
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学位授与年月日 |
2023-03-23 |
| 学位名 |
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学位名 |
博士（栄養学） |
| 学位授与機関 |
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|
学位授与機関名 |
徳島大学 |
k3706_abstract_review.pdf (179 KB)
