| Item type |
文献 / Documents(1) |
| 公開日 |
2023-06-15 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
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|
関連識別子 |
https://doi.org/10.2152/jmi.70.66 |
|
|
関連名称 |
10.2152/jmi.70.66 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Effect of daikenchuto (TU-100) on carcinogenesis in non-alcoholic steatohepatitis |
| タイトル別表記 |
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その他のタイトル |
Effect of TU-100 in NASH |
| 著者 |
山田, 眞一郎
森根, 裕二
居村, 暁
池本, 哲也
齋藤, 裕
(市村)清水, 真祐子
常山, 幸一
ニシヤマ, ミツエ
イシザワ, シオリ
島田, 光生
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| 抄録 |
|
|
内容記述 |
Background : Non-alcoholic steatohepatitis (NASH) is associated with a higher risk of hepatocellular carcinoma (HCC), and the importance of the gut–liver axis has been recognized in NASH-associated HCC. We investigated the effect of TU-100 on the intestinal microbiome and hepatocarcinogenesis in a NASH model. Methods : Seven-week-old Tsumura Suzuki obese diabetes mice, a model that shows the spontaneous onset of NASH and HCC, were used. They were divided into a TU-100 treated group and a control group. Mice were sacrificed at 24 and 48 weeks to evaluate hepatic steatosis, fibrosis, carcinogenesis, cytokine expression, and microbiome abundance. Results : At 24 weeks, the TU-100 group showed significantly lower expression of IL6, IL1B, and ACTA2 mRNA in the liver (P < 0.05). At 48 weeks, the TU-100 group showed significantly lower levels of serum alanine aminotransferase. The TU-100 group also showed a lower rate of NASH than the control group (28% vs 72% ; P = 0.1). Tumor diameter was significantly smaller in the TU-100 group compared with that in the control group (P < 0.05). Regarding the intestinal microbiome, the genera Blautia and Ruminococcus were increased in the TU-100 group (P < 0.05), whereas Dorea and Erysipelotrichaceae were decreased in the TU-100 group (P < 0.05). Conclusions : TU-100 regulates the intestinal microbiome and may suppress subsequent hepatocarcinogenesis in the NASH model. |
| キーワード |
|
|
主題 |
NASH |
| キーワード |
|
|
主題 |
HCC |
| キーワード |
|
|
主題 |
hepatocarcinogenesis |
| キーワード |
|
|
主題 |
TU-100 |
| キーワード |
|
|
主題 |
microbiome |
| 書誌情報 |
en : The Journal of Medical Investigation
巻 70,
号 1-2,
p. 66-73,
発行日 2023-02
|
| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13496867 |
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13431420 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| 出版者 |
|
|
出版者 |
Tokushima University Faculty of Medicine |
| EID |
|
|
識別子 |
396661 |
| 言語 |
|
|
言語 |
eng |
jmi_70_1-2_66.pdf (792 KB)
