| Item type |
文献 / Documents(1) |
| 公開日 |
2023-06-15 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
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|
関連識別子 |
https://doi.org/10.2152/jmi.70.80 |
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関連名称 |
10.2152/jmi.70.80 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
The impact of nutritional status and changes of body composition on the prognosis of metastatic renal cell carcinoma patients |
| タイトル別表記 |
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その他のタイトル |
Impact of body composition on mRCC Prognosis |
| 著者 |
オザキ, ケイスケ
布川, 朋也
大豆本, 圭
佐々木, 雄太郎
ウエノ, ヨシテル
津田, 恵
内田, 貴之
楠原, 義人
山本, 恭代
山口, 邦久
高橋, 正幸
金山, 博臣
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| 抄録 |
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内容記述 |
Purpose : This study aimed to analyze the impact of patients’ nutritional status and changes in body composition on the prognosis of metastatic renal cell carcinoma (mRCC) patients who received systemic therapy with tyrosine kinase inhibitors (TKIs). Methods : A total of 57 mRCC patients who received systemic therapy with TKIs as first-line therapy at our facility between November 2004 and October 2018 were included. The Prognostic Nutritional Index (PNI) was used to evaluate their nutritional status. The volumes of skeletal muscle mass and fat tissue were calculated using the SYNAPSE VINCENT system. The effects of nutritional status and body composition of mRCC patients on progression-free survival (PFS) and overall survival (OS) were analyzed using Cox regression methods. Results : Low PNI at the start of systemic therapy was a significant prognostic predictor for OS (HR 3.807 [95% CI 1.205-12.027], P = 0.046), and it was related to loss of muscle mass three months after systemic therapy. Although the loss of muscle mass at the start of systemic therapy was not associated with OS, loss of muscle mass during treatment predicted worse OS. Conclusions : Nutritional status of mRCC patients may predict changes in body composition and be associated with their prognosis. |
| キーワード |
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|
主題 |
Renal cell carcinoma |
| キーワード |
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|
主題 |
Nutritional status |
| キーワード |
|
|
主題 |
Body composition |
| キーワード |
|
|
主題 |
Tyrosine kinase inhibitor |
| 書誌情報 |
en : The Journal of Medical Investigation
巻 70,
号 1-2,
p. 80-87,
発行日 2023-02
|
| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13496867 |
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13431420 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| 出版者 |
|
|
出版者 |
Tokushima University Faculty of Medicine |
| EID |
|
|
識別子 |
399093 |
| 言語 |
|
|
言語 |
eng |
jmi_70_1-2_80.pdf (526 KB)
