| Item type |
文献 / Documents(1) |
| 公開日 |
2023-07-06 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
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|
関連識別子 |
https://doi.org/10.2152/jmi.70.166 |
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関連名称 |
10.2152/jmi.70.166 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Effects of polymethoxyflavonoids on T helper 17 cell differentiation in vitro and in vivo |
| タイトル別表記 |
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その他のタイトル |
Polymethoxyflavonids and T helper 17 cells |
| 著者 |
中本, 晶子
ヒラバヤシ, ユウワ
アンザキ, チエリ
中本, 真理子
首藤, 恵泉
ニイ, ヨシタカ
酒井, 徹
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| 抄録 |
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内容記述 |
We examined the effects of polymethoxyflavonoids (PMFs) on T helper (Th) 17 cell differentiation in vitro and in vivo. Five different PMFs including nobiletin (NOB), sudachitin (SUD), demethoxysudachitin, heptamethoxyflavone and natsudaidain were used for the in vitro study, and effects of those flavonoids on Th17 responses were investigated. NOB and heptamethoxyflavone significantly suppressed the proliferation response, but SUD, demethoxysudachitin and natsudaidain did not suppress the proliferation response. All of the five flavonoids decreased IL-17A production. Mice with experimentally induced autoimmune encephalomyelitis were used as an in vivo Th17 differentiation model. We focused on two flavonoids, NOB and SUD, and examined the effects of those flavonoids. NOB significantly suppressed Th17 cell proliferation and cytokine responses, but SUD only decreased proliferation responses. The results suggest that the suppressive effect of NOB on Th17 response in vivo is stronger than that of SUD. |
| キーワード |
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|
主題 |
polymethoxyflavonoids |
| キーワード |
|
|
主題 |
nobiletin |
| キーワード |
|
|
主題 |
sudachitin |
| キーワード |
|
|
主題 |
T helper 17 cell |
| キーワード |
|
|
主題 |
IL-17A |
| 書誌情報 |
en : The Journal of Medical Investigation
巻 70,
号 1-2,
p. 166-170,
発行日 2023-02
|
| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13496867 |
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13431420 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| 出版者 |
|
|
出版者 |
Tokushima University Faculty of Medicine |
| EID |
|
|
識別子 |
398463 |
| 言語 |
|
|
言語 |
eng |
jmi_70_1-2_166.pdf (906 KB)
