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糖尿病性腎症から慢性腎臓病治療への新規治療戦略
https://tokushima-u.repo.nii.ac.jp/records/2011169
https://tokushima-u.repo.nii.ac.jp/records/2011169084dec01-2048-4ffc-84b7-05c714efa3ae
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
sam_79_1-2_73.pdf (3.28 MB)
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| Item type | 文献 / Documents(1) | |||||||||||
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| 公開日 | 2023-08-25 | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| 出版社版DOI | ||||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | https://doi.org/10.57444/shikokuactamedica.79.1.2_73 | |||||||||||
| 言語 | ja | |||||||||||
| 関連名称 | 10.57444/shikokuactamedica.79.1.2_73 | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| タイトル | ||||||||||||
| タイトル | 糖尿病性腎症から慢性腎臓病治療への新規治療戦略 | |||||||||||
| 言語 | ja | |||||||||||
| タイトル別表記 | ||||||||||||
| その他のタイトル | The novel strategy to treat diabetic nephropathy and chronic kidney disease | |||||||||||
| 言語 | en | |||||||||||
| タイトル別表記 | ||||||||||||
| その他のタイトル | 糖尿病性腎症の臨床経過 | |||||||||||
| 言語 | ja | |||||||||||
| 著者 |
𦚰野, 修
× 𦚰野, 修
WEKO
1429
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| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Diabetic nephropathy（DN） has been a leading cause of the initiation of dialysis in Japan. We have concentrated on the research on the pathogenesis of DN and focused on the relevant role of proximal tubular（PT） cells based on the concept that DN is a metabolic disease on the kidney. We have identified Sirtuin molecule that was shown to be related to the lifespan of various organisms as a player in the initiation of DN in the early stage before the onset albuminuria. We have established the working hypothesis “Tubular-glomerular interaction”. Another important molecule which draws an attention in this field is sodium-coupled glucose co-transporter 2（SGLT2） which is expressed in PT and reabsorbs glucose from primary filtrate from the glomerulus. The recent clinical trials using SGLT2 inhibitor demonstrated the renoprotective effects on the DN as well as non-DN chronic kidney disease（CKD）. At present, SGLT2 inhibitor can be prescribed for the treatment to DN as well as non-DN CKD. Finally, mineralocorticoid receptor（MR） antagonist（MRA） is another reagent for the treatment of DN. Non-epithelial cells in the kidney expresses MR such as mesangial dells, podocytes, or glomerular endothelial cells. Last year it was published that MRA can retard the progression of DN and reduced the renal specific outcomes. MRA, finerenone, became available for the treatment of DN. Before that we have reported that the high serum aldosterone levels are an independent risk factors for the progression of CKD and MRA can reduce eGFR decline of CKD patients. The future picture of kidney disease will change profoundly owing to the newly developed drug, such as SGLT2 inhibitor or MRA. I have now challenged to develop new health-care system for the identification of CKD patients at the early stage. | |||||||||||
| 言語 | en | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | diabetic nephropathy | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | proximal tubules | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | SGLT2 inhibitor | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | mineralocorticoid receptor antagonist | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | health-care system | |||||||||||
| 書誌情報 |
ja : 四国医学雑誌 en : Shikoku Acta Medica 巻 79, 号 1-2, p. 73-78, 発行日 2023-06-07 |
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| 収録物ID | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 27583279 | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | 徳島医学会 | |||||||||||
| 言語 | ja | |||||||||||
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| 識別子 | 411352 | |||||||||||
| 識別子タイプ | URI | |||||||||||
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| 言語 | jpn | |||||||||||
