| Item type |
文献 / Documents(1) |
| 公開日 |
2023-08-22 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1111/j.1464-5491.2007.02315.x |
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言語 |
ja |
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|
関連名称 |
10.1111/j.1464-5491.2007.02315.x |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
The association of genetic variants in Krüppel-like factor 11 and Type 2 diabetes in the Japanese population |
|
言語 |
de |
| タイトル別表記 |
|
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その他のタイトル |
KLF11 and association study in Japanese |
|
言語 |
en |
| 著者 |
棚橋, 俊仁
シノハラ
Keshavarz, P.
長﨑, 裕加
宮脇, 克行
クニカ
森谷, 眞紀
ナカムラ
吉川, 敏一
塩田, 洋
井上, 寛
板倉, 光夫
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Aims: Krüppel-like factor 11 (KLF11) is a transcriptional factor of the zinc finger domain family that regulates the expression of insulin. In North European populations, its common functional variant Q62R (rs35927125) is a strong genetic factor for Type 2 diabetes (P = 0.00033, odds ratio for G allele = 1.29, 95% CI 1.12–1.49). We examined the contribution of KLF11 variants to the susceptibility to Type 2 diabetes in a Japanese population.
Methods: By re-sequencing Japanese individuals (n = 24, partly 96), we screened all four exons, exon/intron boundaries and flanking regions of KLF11. Verified single nucleotide polymorphisms (SNPs) were genotyped in 731 initial samples (369 control and 362 case subjects). Subsequently, we tested for association in 1087 samples (524 control and 563 case subjects), which were collected in different districts of Japan from the initial samples.
Results: We identified eight variants, including a novel A/C variant on intron 3, but no mis-sense mutations. In an association study, we failed to find any significant result of SNPs (minor allele frequency 8.2–46.2%) after correcting for multiple testing. Similarly, no haplotypes were associated with Type 2 diabetes. It is notable that the G allele in rs35927125 was completely absent in 1818 Japanese individuals.
Conclusions: Genetic variants in KLF11 are unlikely to have a major effect of Type 2 diabetes in the Japanese population, although they were significantly associated in North European populations. These observations might help to determine the role of KLF11 variants in Type 2 diabetes in different populations. |
|
言語 |
en |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
association study |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Japanese |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
KLF11 |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Type 2 diabetes |
| 書誌情報 |
en : Diabetic Medicine
巻 25,
号 1,
p. 19-26,
発行日 2008-01-10
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
14645491 |
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
07423071 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA1063816X |
| 出版者 |
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|
出版者 |
Diabetes UK |
|
言語 |
en |
| 出版者 |
|
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出版者 |
Wiley |
|
言語 |
en |
| 権利情報 |
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|
言語 |
en |
|
権利情報 |
Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation. |
| EID |
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|
識別子 |
187113 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
dm_25_1_19.pdf (364 KB)
