| Item type |
文献 / Documents(1) |
| 公開日 |
2023-08-22 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.3390/nu14030580 |
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関連名称 |
10.3390/nu14030580 |
| 出版タイプ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
Ecklonia stolonifera Okamura Extract Suppresses Myocardial Infarction-Induced Left Ventricular Systolic Dysfunction by Inhibiting p300-HAT Activity |
| 著者 |
カタギリ, タカヒロ
スナガワ, ヨウイチ
マエカワ, タツヤ
船本, 雅文
シミズ, サトシ
シミズ, カナ
カタナサカ, ヤスフミ
コミヤマ, マキ
Hawke, Philip
ハラ, ヒデオ
モリ, キヨシ
ハセガワ, コウジ
モリモト, タツヤ
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| 抄録 |
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内容記述 |
Ecklonia stolonifera Okamura extract (ESE) has been reported to have various bioactive effects, but its effects on cardiovascular disease have not yet been investigated. First, primary neonatal rat cultured cardiomyocytes were treated with ESE and stimulated with phenylephrine (PE) for 48 h. ESE (1000 µg/mL) significantly suppressed PE-induced cardiomyocyte hypertrophy, hypertrophy-related gene transcription, and the acetylation of histone H3K9. An in vitro p300-HAT assay indicated that ESE directly inhibited p300-HAT activity. Next, one week after myocardial infarction (MI) surgery, rats (left ventricular fractional shortening (LVFS) < 40%) were randomly assigned to three groups: vehicle (saline, n = 9), ESE (0.3 g/kg, n = 10), or ESE (1 g/kg, n = 10). Daily oral administration was carried out for 8 weeks. After treatment, LVFS was significantly higher in the ESE (1 g/kg) group than in the vehicle group. The ESE treatments also significantly suppressed MI-induced increases in myocardial cell diameter, perivascular fibrosis, hypertrophy- and fibrosis-related gene transcription, and the acetylation of histone H3K9. These results suggest that ESE suppressed both hypertrophic responses in cardiomyocytes and the development of heart failure in rats by inhibiting p300-HAT activity. Thus, this dietary extract is a potential novel therapeutic strategy for heart failure in humans. |
| キーワード |
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|
主題 |
Ecklonia stolonifera Okamura |
| キーワード |
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|
主題 |
heart failure |
| キーワード |
|
|
主題 |
myocardial infarction |
| キーワード |
|
|
主題 |
p300 |
| キーワード |
|
|
主題 |
HAT activity |
| 書誌情報 |
en : Nutrients
巻 14,
号 3,
p. 580,
発行日 2022-01-28
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
20726643 |
| 出版者 |
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出版者 |
MDPI |
| 権利情報 |
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|
権利情報 |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| EID |
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|
識別子 |
398896 |
| 言語 |
|
|
言語 |
eng |
nu_14_3_580.pdf (894 KB)
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