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Genome-wide methylation profiling identifies a novel gene signature for patients with synchronous colorectal cancer
https://tokushima-u.repo.nii.ac.jp/records/2011204
https://tokushima-u.repo.nii.ac.jp/records/201120484a2e8d7-57be-4f6a-83f7-f225097deea4
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
bjc_128_1_112.pdf (1.67 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||
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| 公開日 | 2024-04-08 | |||||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1038/s41416-022-02033-9 | |||||||||||||||||||||||
| 関連名称 | 10.1038/s41416-022-02033-9 | |||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | Genome-wide methylation profiling identifies a novel gene signature for patients with synchronous colorectal cancer | |||||||||||||||||||||||
| タイトル別表記 | ||||||||||||||||||||||||
| その他のタイトル | Genomewide methylation profiling identifies a novel gene signature for patients with synchronous colorectal cancer | |||||||||||||||||||||||
| タイトル別表記 | ||||||||||||||||||||||||
| その他のタイトル | Methylation signature for synchronous CRC | |||||||||||||||||||||||
| 著者 |
岡田, 泰行
× 岡田, 泰行
WEKO
1412
× Peng, Fuduan
× Perea, José
× Corchete, Luis
× Bujanda, Luis
× Li, Wei
× Goel, Ajay
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| 抄録 | ||||||||||||||||||||||||
| 内容記述 | Background: There are no robust tools for the diagnosis of synchronous colorectal cancer (SyCRC). Herein, we developed the first methylation signature to identify and characterize patients with SyCRC. Methods: For biomarker discovery, we analyzed the genome-wide methylation profiles of 16 SyCRC and 18 solitary colorectal cancer (SoCRC) specimens. We thereafter established a methylation signature risk-scoring model to identify SyCRC in an independent cohort of 38 SyCRC and 42 SoCRC patients. In addition, we evaluated the prognostic value of the identified methylation profile. Results: We identified six differentially methylated CpG probes/sites that distinguished SyCRC from SoCRC. In the validation cohort, we developed a methylation panel that identified patients with SyCRC from not only larger tumor (AUC=0.91) but also the paired remaining tumor (AUC=0.93). Moreover, high risk scores of our panel were associated with the development of metachronous CRC among patients with SyCRC (AUC=0.87) and emerged as an independent predictor for relapse-free survival (hazard ratio=2.72; 95% CI=1.12–6.61). Furthermore, the risk stratification model which combined with clinical risk factors was a diagnostic predictor of recurrence (AUC=0.90). Conclusions: Our novel six-gene methylation panel robustly identifies patients with SyCRC, which has the clinical potential to improve the diagnosis and management of patients with CRC. |
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| キーワード | ||||||||||||||||||||||||
| 主題 | synchronous colorectal cancer | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | gene methylation | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | predictive biomarker | |||||||||||||||||||||||
| 書誌情報 |
en : British Journal of Cancer 巻 128, 号 1, p. 112-120, 発行日 2022-11-01 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 00070920 | |||||||||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 15321827 | |||||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||||
| 収録物識別子 | AA00574355 | |||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||
| 出版者 | Springer Nature | |||||||||||||||||||||||
| 備考 | ||||||||||||||||||||||||
| 値 | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use (https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms), but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1038/s41416-022-02033-9 | |||||||||||||||||||||||
| EID | ||||||||||||||||||||||||
| 識別子 | 399618 | |||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||
