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Nanoparticles Encapsulated γ-Oryzanol as a Natural Prodrug of Ferulic Acid for the Treatment of Oxidative Liver Damage
https://tokushima-u.repo.nii.ac.jp/records/2011214
https://tokushima-u.repo.nii.ac.jp/records/20112145659b97b-68cf-4042-b424-4f1ecaf3531f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
bpb_46_10_1403.pdf (2.93 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||
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| 公開日 | 2023-10-11 | |||||||||||||
| アクセス権 | ||||||||||||||
| アクセス権 | open access | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | journal article | |||||||||||||
| 出版社版DOI | ||||||||||||||
| 関連識別子 | https://doi.org/10.1248/bpb.b23-00181 | |||||||||||||
| 関連名称 | 10.1248/bpb.b23-00181 | |||||||||||||
| 出版タイプ | ||||||||||||||
| 出版タイプ | VoR | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Nanoparticles Encapsulated γ-Oryzanol as a Natural Prodrug of Ferulic Acid for the Treatment of Oxidative Liver Damage | |||||||||||||
| 著者 |
Ara, Tabassum
× Ara, Tabassum
× 小暮, 健太朗
WEKO
1139
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| 抄録 | ||||||||||||||
| 内容記述 | Antioxidants are promising therapeutics for treating oxidative stress-mediated liver diseases. Previously, we studied a potent natural antioxidant, ferulic acid, and developed a liposomal formulation of ferulic acid (ferulic-lipo) to improve its solubility. Ferulic-lipo significantly attenuated oxidative damage in the liver by inhibiting reactive oxygenase species (ROS). However, antioxidative liposomes must be less reactive with ROS prior to reaching the target sites to effectively neutralize existing ROS. But ferulic-lipo tends to be oxidized before reaching the liver. Besides, γ-oryzanol has been reported to decompose into ferulic acid in vivo; accordingly, we hypothesized that γ-oryzanol could be employed as a natural prodrug of ferulic acid to improve stability and antioxidative effectiveness. Therefore, in this study, we prepared a liposomal formulation of γ-oryzanol (γ-ory-lipo) and investigated its therapeutic effects in a CCl4-induced rat model of liver injury. We found that γ-ory-lipo has a higher chemical stability than does free γ-oryzanol. Although the antioxidative effect of γ-ory-lipo was lower than that of ferulic-lipo, pretreatment of the HepG2 cells with γ-ory-lipo improved the viability of CCl4-treated cells to a similar level as treatment with ferulic-lipo. γ-Oryzanol was shown to be converted into ferulic acid in vitro and in vivo. Furthermore, intravenous administration of γ-ory-lipo exhibited a similar effectiveness as ferulic-lipo against CCl4-induced hepatotoxicity, which should be the due to the conversion of γ-oryzanol into ferulic acid. These findings demonstrated that γ-ory-lipo could be a good natural prodrug of ferulic acid for eradicating its stability problem. | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | γ-oryzanol | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | prodrug | |||||||||||||
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| 主題 | stability | |||||||||||||
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| 主題 | liposome | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | oxidative-stress | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | antioxidant | |||||||||||||
| 書誌情報 |
en : Biological and Pharmaceutical Bulletin 巻 46, 号 10, p. 1403-1411, 発行日 2023-10-01 |
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| 収録物ID | ||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||
| 収録物識別子 | 13475215 | |||||||||||||
| 収録物ID | ||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||
| 収録物識別子 | 09186158 | |||||||||||||
| 収録物ID | ||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||
| 収録物識別子 | AA11696048 | |||||||||||||
| 出版者 | ||||||||||||||
| 出版者 | The Pharmaceutical Society of Japan | |||||||||||||
| EID | ||||||||||||||
| 識別子 | 400092 | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
