WEKO3
アイテム
Hemodynamic impact of ephedrine on hypotension during general anesthesia : a prospective cohort study on middle-aged and older patients
https://tokushima-u.repo.nii.ac.jp/records/2011261
https://tokushima-u.repo.nii.ac.jp/records/2011261fd7f989e-d459-467b-9fbc-912464a275b7
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k3832_abstract.pdf (196 KB)
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k3832_review.pdf (108 KB)
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k3832_fulltext.pdf (1.06 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||
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| 公開日 | 2023-09-27 | |||||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||||||||||||||||
| 資源タイプ | doctoral thesis | |||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1186/s12871-023-02244-4 | |||||||||||||||||||||||
| 関連名称 | 10.1186/s12871-023-02244-4 | |||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||
| 出版タイプ | NA | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | Hemodynamic impact of ephedrine on hypotension during general anesthesia : a prospective cohort study on middle-aged and older patients | |||||||||||||||||||||||
| タイトル別表記 | ||||||||||||||||||||||||
| その他のタイトル | 全身麻酔中におけるエフェドリンの昇圧効果：中年および高齢者に対する前向きコホート研究 | |||||||||||||||||||||||
| 著者 |
植村, 勇太
× 植村, 勇太× 木下, 倫子
WEKO
453
× 酒井, 陽子
WEKO
656
× 田中, 克哉
WEKO
1645
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| 内容記述 | Background Ephedrine is a mixed α- and β-agonist vasopressor that is frequently used for the correction of hypotension during general anesthesia. β-responsiveness has been shown to decrease with age; therefore, this study aimed to determine whether aging would reduce the pressor effect of ephedrine on hypotension during general anesthesia. Methods Seventy-five patients aged ≥ 45 years were included in this study, with 25 patients allocated to each of the three age groups: 45–64 years, 65–74 years, and ≥ 75 years. All patients received propofol, remifentanil, and rocuronium for the induction of general anesthesia, followed by desflurane and remifentanil. Cardiac output (CO) was estimated using esCCO technology. Ephedrine (0.1 mg/kg) was administered for the correction of hypotension. The primary and secondary outcome measures were changes in the mean arterial pressure (MAP) and CO, respectively, at 5 min after the administration of ephedrine. Results The administration of ephedrine significantly increased MAP (p < 0.001, mean difference: 8.34 [95% confidence interval (CI), 5.95–10.75] mmHg) and CO (p < 0.001, mean difference: 7.43 [95% CI, 5.20–9.65] %) across all groups. However, analysis of variance revealed that the degree of elevation of MAP (F [2, 72] = 0.546, p = 0.581, η2 = 0.015 [95% CI, 0.000–0.089]) and CO (F [2, 72] = 2.023, p = 0.140, η2 = 0.053 [95% CI, 0.000–0.162]) did not differ significantly among the groups. Similarly, Spearman’s rank correlation and multiple regression analysis revealed no significant relation between age and the changes in MAP or CO after the administration of ephedrine. Conclusion The administration of ephedrine significantly increased MAP and CO; however, no significant correlation with age was observed in patients aged > 45 years. These findings suggest that ephedrine is effective for the correction of hypotension during general anesthesia, even in elderly patients. |
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| キーワード | ||||||||||||||||||||||||
| 主題 | Aging | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | Elderly | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | Ephedrine | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | Hemodynamics | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | Hypotension | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | General anesthesia | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | ephedrine | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | hypotension | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | oldwe patients | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | hemodynamic | |||||||||||||||||||||||
| 書誌情報 |
en : BMC Anesthesiology 巻 23, p. 283, 発行日 2023-08-22 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 14712253 | |||||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||||
| 収録物識別子 | AA12034694 | |||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||
| 出版者 | BioMed Central | |||||||||||||||||||||||
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| 出版者 | Springer Nature | |||||||||||||||||||||||
| 備考 | ||||||||||||||||||||||||
| 値 | 内容要旨・審査要旨・論文本文の公開 本論文は，著者Yuta Uemuraの学位論文として提出され，学位審査・授与の対象となっている。 学位授与者所属 : 徳島大学大学院医学研究科（医学専攻） |
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| 権利情報 | ||||||||||||||||||||||||
| 権利情報 | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. | |||||||||||||||||||||||
| EID | ||||||||||||||||||||||||
| 識別子 | 402446 | |||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||
| 報告番号 | ||||||||||||||||||||||||
| 学位授与番号 | 甲第3832号 | |||||||||||||||||||||||
| 学位記番号 | ||||||||||||||||||||||||
| 値 | 甲医第1610号 | |||||||||||||||||||||||
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| 学位授与年月日 | 2024-04-25 | |||||||||||||||||||||||
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| 学位名 | 博士（医学） | |||||||||||||||||||||||
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| 学位授与機関名 | 徳島大学 | |||||||||||||||||||||||
